Technetium-99m-exametazine: Pitfalls in preparation and quality control
- Loyola Univ. of Medical Center, Maywood, IL (USA)
The Food and Drug Administration recently approved the drug exametazine (Cretec or hexamethylenepropylene-amineoxime) for use in preparation of a {sup 99m}Tc-chelate suitable for human use. This radiopharmaceutical is indicated for detection of altered regional cerebral perfusion in patients with stoke. Unlike the majority of radiopharmaceuticals containing stannous ion (Sn{sup 2+}), which can be prepared by addition of varying volumes and activities of ({sup 99m}Tc)pertechnetate, successful preparation of {sup 99m}Tc-exametazime requires careful control of both volume and activity. The necessity for careful control of the final chemical concentration and radioconcentration is based on the minimal amount of Sn{sup 2+} ion present.
- OSTI ID:
- 6698509
- Journal Information:
- Journal of Nuclear Medicine Technology; (USA), Vol. 17:4; ISSN 0091-4916
- Country of Publication:
- United States
- Language:
- English
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RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
VASCULAR DISEASES
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CEREBRUM
ISOMERIC NUCLEI
OXIMES
PATIENTS
PERFUSED TISSUES
PERTECHNETATES
QUALITY CONTROL
TECHNETIUM 99
TECHNETIUM COMPOUNDS
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US FDA
AMINES
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
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BRAIN
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HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NATIONAL ORGANIZATIONS
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NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
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REFRACTORY METAL COMPOUNDS
SYNTHESIS
TECHNETIUM ISOTOPES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics