Radiation decomposition of technetium-99m radiopharmaceuticals. [Glucnates, pyrophosphates, and serum albumins]

Journal Article · Wed Jan 31 23:00:00 EST 1979 · J. Nucl. Med.; (United States)

OSTI ID:6168703

Billinghurst, M W; Rempel, S; Westendorf, B A

Technetium-99m radiopharmaceuticals are shown to be subject to autoradiation-induced decomposition, which results in increasing abundance of pertechnetate in the preparation. This autodecomposition is catalyzed by the presence of oxygen, although the removal of oxygen does not prevent its occurrence. The initial appearance of pertechnetate in the radiopharmaceutical is shown to be a function of the amount of radioactivity, the quantity of stannous ion used, and the ratio of /sup 99m/Tc to total technetium in the preparation.

• Research Organization: Health Sciences Centre, Winnipeg, Manitoba
• OSTI ID: 6168703
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
560111 -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
AUTOLYSIS
AUTORADIOLYSIS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
CRYOGENIC FLUIDS
DECOMPOSITION
DRUGS
ELEMENTS
FLUIDS
GLUCONIC ACID
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXYGEN
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PROTEINS
PYROPHOSPHATES
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOLYSIS
RADIOPHARMACEUTICALS
RADIOSENSITIVITY EFFECTS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIME DEPENDENCE
TIN COMPOUNDS
YEARS LIVING RADIOISOTOPES