Technetium-99m radiopharmaceutical preparation by surface adsorbed stannous ions
A method of producing technetium-99m (/sup 99m/Tc) radiopharmaceuticals is described, where reduction of pertechnetate occurs through stannous ions adsorbed on the surface of an infusion catheter. This leads to radiopharmaceuticals containing microgram quantities of stannous ions and that, therefore, results in minimal blood-pool labeling and essentially the elimination of tin colloids. Other advantages of the method include a reduction in quantities of ligand required and the possibility to mass produce the tinned catheters as technetium reduction kits. A wide variety of /sup 99m/Tc radiopharmaceuticals have been prepared in high yield. Excellent biodistribution in several of these is demonstrated.
- Research Organization:
- Royal Melbourne Hospital, Parkville, Victoria, Australia
- OSTI ID:
- 6331857
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 6; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ADSORPTION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL PREPARATION
DISTRIBUTION
DRUGS
ELEMENTS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
METALS
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
RADIOPHARMACEUTICALS
SORPTION
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIN
TISSUE DISTRIBUTION
YEARS LIVING RADIOISOTOPES