Correlation of chromosome patterns in leukemic cells of patients with exposure to chemicals and/or radiation

Technical Report · Wed Aug 01 00:00:00 EDT 1990

OSTI ID:6582565

Rowley, J D

Progress made in understanding the molecular genetics of leukemia is described. We have had remarkable success in applying the new techniques of using nonradiolabeled DNA probes to identify chromosome abnormalities more precisely. We have continued to update our series of patients who have treatment related acute myeloid leukemia (AML) and myelodysplasia (MDS). We have identified malignant cells in five adult patients with MDS or AML. Also discussed is mapping DNA probes to chromosome 5.5 refs., 5 figs., 5 tabs.

• Research Organization: Chicago Univ., IL (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-86ER60408
• OSTI ID: 6582565
• Report Number(s): DOE/ER/60408-2; ON: DE90017603
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMAL ABERRATIONS
GENETIC MAPPING
LEUKEMOGENESIS
MOLECULAR BIOLOGY
ANIMAL CELLS
BIOLOGICAL MARKERS
CHROMOSOMES
CORRELATIONS
DNA
DNA HYBRIDIZATION
GENE RECOMBINATION
HETEROCHROMOSOMES
HUMAN CHROMOSOME 5
LEUKEMIA
MAN
PHOSPHOTRANSFERASES
PROBES
PROGRESS REPORT
THERAPY
TUMOR CELLS
YEASTS
ANIMALS
CARCINOGENESIS
DISEASES
DOCUMENT TYPES
ENZYMES
EUMYCOTA
FUNGI
HEMIC DISEASES
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
MAMMALS
MAPPING
MICROORGANISMS
MUTATIONS
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
PHOSPHORUS-GROUP TRANSFERASES
PLANTS
PRIMATES
TRANSFERASES
VERTEBRATES
550400* - Genetics
550900 - Pathology
550200 - Biochemistry