Correlation of chromosome patterns in leukemic cells of patients with exposure to chemicals and/or radiation

Technical Report · Sun Oct 01 04:00:00 EDT 1989

DOI:https://doi.org/10.2172/5546629· OSTI ID:5546629

Rowley, J. D.

We have identified two new recurring translocations involving chromosome 5; one is a 3;5 translocation and the other involves a rearrangement between chromosomes 5 and 7. The first is t(3;5)(q25.1;q35). We studied five patients with AML and a t(3;5) in their leukemic cells. At diagnosis, four of the patients had a t(3;5) as their sole karyotypic anomaly; the remaining patient had additional structural and numerical abnormalities. Careful cytogenetic analysis indicated that the breakpoints of this rearrangement were 3q25.1 and 5q34, in contrast to the various breakpoints reported in earlier studies (3q21 to 3q25 and 5q31 to 5q35). The karyotypic, morphologic, and clinical characteristics of this group, as well as those of 15 previously reported patients with the t(3;5), were compared to identify any features that might warrant consideration of this anomaly as a specific syndrome. The median age of the group, 37 years, as younger than that of all patients with AML, 49 years. A preceding myelodysplastic syndrome was observed in three patients. We have no information regarding the occupation of most of these patients. Except for acute promyelocytic leukemia, each morphologic subtype occurred in these patients; however, the frequency of erythroleukemia (M6) was much greater than expected. 11 refs., 2 figs., 5 tabs.

• Research Organization: Chicago Univ., IL (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-86ER60408
• OSTI ID: 5546629
• Report Number(s): DOE/ER/60408-T3; ON: DE90001227
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGY
CARCINOGENESIS
CHEMOTHERAPY
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CLONING
DISEASES
DNA HYBRIDIZATION
DNA-CLONING
DOCUMENT TYPES
ENZYMES
GENETIC MAPPING
GENETICS
GLOBULINS
GROWTH FACTORS
HEMIC DISEASES
HUMAN CHROMOSOME 5
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
IMMUNOGLOBULINS
LEUKEMIA
LEUKEMOGENESIS
MAMMALS
MAN
MAPPING
MITOGENS
MOLECULAR BIOLOGY
MUTATIONS
NEOPLASMS
ORGANIC COMPOUNDS
PATHOGENESIS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PRIMATES
PROGRESS REPORT
PROTEINS
THERAPY
TRANSFERASES
TUMOR CELLS
VERTEBRATES