Correlation of chromosome patterns in human leukemic cells with exposure to chemicals and/or radiation
Technical Report
·
OSTI ID:5671173
This document lists the major accomplishments funded by DOE in the period of January 1989 through June 1991. Specific topics covered include: studies of chromosome translocations in patients with Acute Myeloid Leukemia (AML) de novo; correlation of karyotype and therapeutic response; the relationship of specific chromosomal abnormalities to a patient's occupational history; definition of regions on chromosome 5 involved in leukemogenesis; the influence of pervious chemotherapy on leukemogenesis; identification of genes at or near breakpoints involved in leukemia and lymphoma; identification of the critical rearrangement in the 9;11 translocation; molecular analysis of translocations involving 11q23; identification of other genes (like RAS) involved in leukemogenesis; development of fluorescence in situ hybridization as a cytogenetic tool; and examination of an unequivocal case of radiation induced preleukemia. 26 refs., 8 figs., 6 tabs.
- Research Organization:
- Chicago Univ., IL (United States)
- Sponsoring Organization:
- DOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-86ER60408
- OSTI ID:
- 5671173
- Report Number(s):
- DOE/ER/60408-T4; ON: DE91015446
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
550400* -- Genetics
550900 -- Pathology
560120 -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BANDING TECHNIQUES
BIOLOGICAL MARKERS
BIOLOGY
CARCINOGENESIS
CHEMOTHERAPY
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
COSMIDS
CYTOLOGICAL TECHNIQUES
DISEASES
DNA
DNA HYBRIDIZATION
DNA SEQUENCING
DOCUMENT TYPES
EUMYCOTA
FUNGI
GENETIC MAPPING
GENETICS
HUMAN CHROMOSOME 5
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
LEUKEMIA
LEUKEMOGENESIS
LYMPHOMAS
MAMMALS
MAN
MAPPING
MICROORGANISMS
MOLECULAR BIOLOGY
MUTATIONS
MYELOID LEUKEMIA
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
PLANTS
PRIMATES
PROBES
PROGRESS REPORT
STRUCTURAL CHEMICAL ANALYSIS
THERAPY
TUMOR CELLS
VERTEBRATES
YEASTS
550400* -- Genetics
550900 -- Pathology
560120 -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BANDING TECHNIQUES
BIOLOGICAL MARKERS
BIOLOGY
CARCINOGENESIS
CHEMOTHERAPY
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
COSMIDS
CYTOLOGICAL TECHNIQUES
DISEASES
DNA
DNA HYBRIDIZATION
DNA SEQUENCING
DOCUMENT TYPES
EUMYCOTA
FUNGI
GENETIC MAPPING
GENETICS
HUMAN CHROMOSOME 5
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
LEUKEMIA
LEUKEMOGENESIS
LYMPHOMAS
MAMMALS
MAN
MAPPING
MICROORGANISMS
MOLECULAR BIOLOGY
MUTATIONS
MYELOID LEUKEMIA
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
PLANTS
PRIMATES
PROBES
PROGRESS REPORT
STRUCTURAL CHEMICAL ANALYSIS
THERAPY
TUMOR CELLS
VERTEBRATES
YEASTS