Correlation of chromosome patterns in human leukemic cells with exposure to chemicals and/or radiation
This project seeks to defining the chromosome segments associated with radiation induced leukemogenesis (treatment-related acute myeloid leukemia, or t-AML). Towards these goals genetic analysis of human chromosomes 5 and 7 continues to investigate correlation of treatment with balanced and unbalanced chromosomal translocations. Progress is being made in cloning the breakpoints in balanced translocations in t-AML, that is to clone the t(9;11) and t(11;19) breakpoints, to clone the t(3;21)(q26;q22) breakpoints and to determine the relationship of these translocations to prior exposure to topoisomerase II inhibitors. 11 figs. 3 figs.
- Research Organization:
- Chicago Univ., IL (United States)
- Sponsoring Organization:
- DOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-86ER60408
- OSTI ID:
- 7206352
- Report Number(s):
- DOE/ER/60408-4; ON: DE92016973
- Country of Publication:
- United States
- Language:
- English
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DOCUMENT TYPES
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HUMAN CHROMOSOME 5
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IMMUNE SYSTEM DISEASES
LEUKEMIA
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MUTANTS
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ORGANIC COMPOUNDS
PATIENTS
PRIMATES
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PROTEINS
RADIATION INDUCED MUTANTS
RADIOINDUCTION
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