Correlation of chromosome patterns in human leukemic cells with exposure to chemicals and/or radiation. Comprehensive progress report, July 1991--June 1992

Technical Report · Mon Jun 01 00:00:00 EDT 1992

DOI:https://doi.org/10.2172/10158086· OSTI ID:10158086

Rowley, J D

This project seeks to defining the chromosome segments associated with radiation induced leukemogenesis (treatment-related acute myeloid leukemia, or t-AML). Towards these goals genetic analysis of human chromosomes 5 and 7 continues to investigate correlation of treatment with balanced and unbalanced chromosomal translocations. Progress is being made in cloning the breakpoints in balanced translocations in t-AML, that is to clone the t(9;11) and t(11;19) breakpoints, to clone the t(3;21)(q26;q22) breakpoints and to determine the relationship of these translocations to prior exposure to topoisomerase II inhibitors. 11 figs. 3 figs.

• Research Organization: Chicago Univ., IL (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-86ER60408
• OSTI ID: 10158086
• Report Number(s): DOE/ER/60408--4; ON: DE92016973
• Country of Publication: United States
• Language: English

Related Subjects

550200
550400
550604
560120
560151
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOCHEMISTRY
CHROMOSOMAL ABERRATIONS
DNA HELICASES
DNA-CLONING
GENETIC MAPPING
GENETICS
HUMAN CHROMOSOME 5
LEUKEMIA
MAN
PATIENTS
PROGRESS REPORT
RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE
RADIATION INDUCED MUTANTS
RADIOINDUCTION
UNSEALED RADIONUCLIDES IN THERAPY