Further studies on the effects of dietary copper deficiency on rat pancreas
The present study was designed to obtain further information on the effect of Cu deficiency on the pancreas and on pancreatic SOD activity. In a series of experiments, groups of male weanling Sprague Dawley rats were fed either a Cu sufficient Cu or Cu deficient purified AIN-'76 diet. Cu levels were determined in blood and selected organs by atomic absorption spectrophotometry. Serum ceruloplasmin, hemoglobin and hematocrit values were determined. Aliquots of homogenized pancreas were assayed for CuSOD, MnSOD and other pancreatic enzyme activities. Although the experimental conditions appeared to be identical to those used in previous experiments, the results were different. In the experiments reported here, even though pancreatic weights decreased by week 7 relative to controls, there was no evidence of pancreatic atrophy. There was no significant decrease in CuSOD, but an unexpected increase in MnSOD activity by week 9 in rats fed Cu-deficient diet. An examination of all data indicates that the difference in results between previous experiments and those reported here was due to the varying degree of Cu deficiency produced: Cu deficiency was less pronounced in the present study.
- Research Organization:
- Chicago State Univ., IL (USA)
- OSTI ID:
- 5941017
- Report Number(s):
- CONF-8805159-
- Journal Information:
- Trace Subst. Environ. Health; (United States), Vol. 12; Conference: 22. annual conference on trace substances in environmental health, St. Louis, MO, USA, 23-26 May 1988
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
COPPER
METABOLISM
SUPEROXIDE DISMUTASE
ENZYME ACTIVITY
ABSORPTION SPECTRA
CERULOPLASMIN
DIET
HEMOGLOBIN
NUTRITIONAL DEFICIENCY
PANCREAS
RATS
ANIMALS
BODY
CARBOXYLIC ACIDS
COMPLEXES
COPPER COMPLEXES
DIGESTIVE SYSTEM
ELEMENTS
ENDOCRINE GLANDS
ENZYMES
GLANDS
GLOBIN
GLOBULINS
GLOBULINS-ALPHA
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MAMMALS
METALLOPROTEINS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PIGMENTS
PORPHYRINS
PROTEINS
RODENTS
SPECTRA
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology