Effect of dietary copper on platelet volume and cytochrome c oxidase (CCO) in platelets

Journal Article · Thu Feb 09 04:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:6929502

Ralston, N V.C.; Milne, D B ^[1]

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1. Dept. of Agriculture, Grand Forks, ND (USA)

Results from a recent study with young women indicated that CCO activity in PLT may be a sensitive indicator of Cu status. Furthermore, abnormal PLT and CuD have been associated with atherosclerosis. Thus, to examine the effect of CuD on PLT variables, weanling male Sprague Dawley or Fisher rats were fed Cu deficient (CuD <1 ppm) or adequate (6 ppm Cu) diets. After 5 weeks, several indices of Cu status, including liver and plasma Cu, and ceruloplasmin were lower in CuD. PLT Cu, CCO and superoxide dismutase (SOD) were lower, and mean platelet volume (MPV) was increased in CuD. In a separate study, CCO activity in PLT was directly correlated with Cu intakes below 5 ppm. These data indicate that CCO in PLT is a sensitive indicator of Cu status and that energy metabolism and resistance to oxidative damage are impaired in PLT from CuD animals. The apparent increased MPV seen in CuD and atherosclerosis may be the result of fewer small PLT. Larger MPV, seen in CuD and atherosclerosis, may lead to increased aggregability and clot formation.

• OSTI ID: 6929502
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (USA) Vol. 3:3; ISSN FAJOE; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism &amp; Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CARDIOVASCULAR DISEASES
CYTOCHROME OXIDASE
DISEASES
ENZYME ACTIVITY
ENZYMES
ETIOLOGY
FEMALES
HAEM DEHYDROGENASES
INJURIES
KINETICS
MAMMALS
MAN
MATERIALS
NUTRITIONAL DEFICIENCY
OXIDOREDUCTASES
PRIMATES
REACTION KINETICS
SUPEROXIDE DISMUTASE
VERTEBRATES
WOMEN