The effects of Cu and Se deficiency on cephaloridine nephrotoxicity in rats

Conference · Sun Mar 10 23:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5300808

Kays, S E; Crowell, W A; Johnson, M A ^[1]

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1. Univ. of Georgia, Athens (United States)

It has been proposed that nephrotoxicity of cephaloridine (CE), a betalactam antibiotic, is mediated via the production of oxygen radicals. Trace elements such as copper (Cu) and selenium (Se) are thought to play a role in protection against oxygen radical damage and Se deficiency has been shown to enhance CE nephrotoxicity. This study was conducted to compare the effects of Cu and Se nutrition on CE nephrotoxicity. Weanling, male, Sprague-Dawley rats were fed adequate, Cu deficient, Se deficient and Se and Cu deficient diets for 4 weeks and subsequently injected i.p. with CE or saline. CE treatment increase plasma urea, kidney weight, excretion of urinary enzymes and kidney pathology and decreased activity of kidney Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and glutathione peroxidase (GSH-Px). Se deficiency decreased kidney GSH-Px activity and increased CE nephrotoxicity with increased plasma urea, kidney weight, excretion of urinary enzymes and kidney pathology. Cu deficiency had no effect on CE nephrotoxicity but resulted in a small depression in kidney Cu,Zn-SOD activity. It is doubtful that the small change in kidney Cu,Zn-SOD activity would be sufficient to impair antioxidant status. In contrast the marked depression in GSH-Px activity during Se deficiency may have impaired antioxidant status, and contributed to an increase in CE nephrotoxicity.

• OSTI ID: 5300808
• Report Number(s): CONF-9104107--
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Vol. 5:4; ISSN 0892-6638; ISSN FAJOE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIOXIDANTS
BIOLOGICAL EFFECTS
COPPER
DRUGS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
MAMMALS
METALS
NONMETALS
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
OXIDOREDUCTASES
OXYGEN
PEROXIDASES
PROTEINS
RADICALS
RATS
RODENTS
SELENIUM
SEMIMETALS
SUPEROXIDE DISMUTASE
TOXICITY
TRANSITION ELEMENTS
VERTEBRATES