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Effects of different levels of selenium administered to rats in drinking water on distribution and glutathione peroxidase

Journal Article · · Res. Commun. Chem. Pathol. Pharmacol.; (United States)
OSTI ID:6468907
; ; ;

Studies were conducted in an attempt to define a biochemical index of selenium toxicity rather than weight loss, liver disease and death. Rats, maintained on selenium deficient diets, received in drinking water various levels of selenium as Na/sub 2/SeO/sub 3/(0.1, 1.0, 1.5, 2.0 ppM). Changes in selenium dependent glutathione peroxidase (GSH-Px) activities and specific activities (nCi/sup 75/ Se/..mu..g Se) were determined in liver, kidney and plasma at baseline and two and ten weeks after repletion. In initial selenium deficient rats, GSH-Px activities were markedly depressed and specific activities elevated as compared to 0.1 ppM controls. After two weeks, liver and plasma GSH-Px activities increased, and plasma, liver and kidney specific activities decreased in a concentration dependent manner. In kidney, there were no differences in enzyme activity at either two or ten weeks. At ten weeks, liver GSH-Px activities continued to increase in the 1.0 ppM group, but were depressed at both the 1.5 and 2.0 ppM levels. Specific activities were also depressed in liver and excretion was not increased at these levels. This suggests a biochemical toxicity in liver at levels above 1.0 ppM after ten weeks, prior to the onset of gross pathological changes.

Research Organization:
Ohio State Univ., Columbus
OSTI ID:
6468907
Journal Information:
Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 21:1; ISSN RCOCB
Country of Publication:
United States
Language:
English

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Related Subjects

550200 -- Biochemistry
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DISTRIBUTION
DRINKING WATER
ELEMENTS
ENZYMES
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
KIDNEYS
LIVER
MAMMALS
METABOLISM
NUTRITIONAL DEFICIENCY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PEROXIDASES
PORPHYRINS
RATS
RODENTS
SELENIUM
SELENIUM COMPOUNDS
SEMIMETALS
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES
WATER