Effects of different levels of selenium administered to rats in drinking water on distribution and glutathione peroxidase
Studies were conducted in an attempt to define a biochemical index of selenium toxicity rather than weight loss, liver disease and death. Rats, maintained on selenium deficient diets, received in drinking water various levels of selenium as Na/sub 2/SeO/sub 3/(0.1, 1.0, 1.5, 2.0 ppM). Changes in selenium dependent glutathione peroxidase (GSH-Px) activities and specific activities (nCi/sup 75/ Se/..mu..g Se) were determined in liver, kidney and plasma at baseline and two and ten weeks after repletion. In initial selenium deficient rats, GSH-Px activities were markedly depressed and specific activities elevated as compared to 0.1 ppM controls. After two weeks, liver and plasma GSH-Px activities increased, and plasma, liver and kidney specific activities decreased in a concentration dependent manner. In kidney, there were no differences in enzyme activity at either two or ten weeks. At ten weeks, liver GSH-Px activities continued to increase in the 1.0 ppM group, but were depressed at both the 1.5 and 2.0 ppM levels. Specific activities were also depressed in liver and excretion was not increased at these levels. This suggests a biochemical toxicity in liver at levels above 1.0 ppM after ten weeks, prior to the onset of gross pathological changes.
- Research Organization:
- Ohio State Univ., Columbus
- OSTI ID:
- 6468907
- Journal Information:
- Res. Commun. Chem. Pathol. Pharmacol.; (United States), Vol. 21:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
PEROXIDASES
METABOLISM
SELENIUM
TISSUE DISTRIBUTION
TOXICITY
BLOOD PLASMA
DRINKING WATER
KIDNEYS
LIVER
NUTRITIONAL DEFICIENCY
RATS
SELENIUM COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
ENZYMES
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PORPHYRINS
RODENTS
SEMIMETALS
VERTEBRATES
WATER
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550200 - Biochemistry