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Effect of selenium depletion and repletion on plasma glutathione

Conference · · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5387265
;

Selenium (Se) deficiency causes a doubling of glutathione (G) concentration in rat plasma. To examine further the effect of Se deficiency on G metabolism the authors studied the time course of Se depletion and repletion. Weanling male Sprague-Dawley rats were fed selenium-deficient (0 Se) or control (C) diet for 10 weeks. Arterial plasma G concentration was determined weekly. Plasma G decreased in C rats until week 5 but after that time remained constant. It remained constant throughout the experiment in 0 Se rats. Thus, plasma g level decreases with age in C but not in 0 Se rats. To determine the level of Se necessary to correct plasma G levels, rats maintained on 0 Se diet for 6 weeks were refed Se (0.015 or 0.030 mg Se/kg diet). After 2 wk supplementation of 0.015 ppm Se, plasma G levels were corrected from 200% to 150% of C; however, there was no increase in liver glutathione peroxidase (GSH-Px) activity. Refeeding of 0.030 ppm Se corrected plasma G levels to 105% of C at 2 wk, but increased liver GSH-Px activity only from 0.4% to 1.8% of C. Thus, as little as 0.030 ppm Se is sufficient to correct plasma G levels but is not sufficient to increase liver GSH-Px to C levels.

Research Organization:
Univ. of Texas Health Science Center, San Antonio
OSTI ID:
5387265
Report Number(s):
CONF-8604222-
Journal Information:
Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:3; ISSN FEPRA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
DIET
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
GLANDS
GLUTATHIONE
LIVER
MAMMALS
MATERIALS
METABOLISM
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEPTIDES
PEROXIDASES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SELENIUM
SEMIMETALS
VERTEBRATES