Effect of dietary copper on platelet volume and aggregation in men

Conference · Fri Mar 15 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5239274

Milne, D B; Gallagher, S K ^[1]

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1. Dept. of Agriculture, Grand Forks, ND (United States)

A study conducted in the authors' laboratory indicated that mean platelet (PLT) volume (MPV) in rats was affected by dietary copper. They suggested that PLT aggregation may also be affected. Ten men aged 19 to 39 yrs, who lived in a metabolic unit, participated in a study that was divided into four six-week dietary periods in a 2 {times} 2 factorial design with 0.65 and 2.65 mg Cu/d and 0.75 and 2.75 g cystine/d as variables. Plasma copper was not significantly affected by the dietary manipulations, but enzymatically measured ceruloplasmin (Cp) was significantly depressed during low copper intake. Maximum 5 {mu}M ADP-stimulated PLT aggregation in platelet rich plasma was significantly greater during low copper intake than during high Cu intake. Total platelet count and collagen or epinephrine stimulated PLT aggregation were not significantly affected by dietary treatment. Four men who responded to low copper intake with elevated serum cholesterol and depressed specific activity of Cp had significantly elevated MPV and maximum ADP-stimulated PLT aggregation during low Cu intake. The other six men exhibited only increased PLT aggregation during only the low copper, low cystine dietary period. These data indicate that dietary copper is a factor in PLT function in humans.

• OSTI ID: 5239274
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:5
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADP
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION
BLOOD PLATELETS
BODY FLUIDS
CERULOPLASMIN
COMPLEXES
COPPER
COPPER COMPLEXES
ELEMENTS
GLOBULINS
GLOBULINS-ALPHA
MAMMALS
MAN
MATERIALS
METABOLISM
METALLOPROTEINS
METALS
NUCLEOTIDES
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
VERTEBRATES
VOLUME