Consequences of copper (Cu) deficiency are not differentially influenced by fructose or starch in growing pigs fed a dried skim milk-based diet

Journal Article · Thu Feb 09 04:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:7190437

Schoenemann, H M; Failla, M L; Fields, M ^[1]

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1. Dept. of Agriculture, Beltsville, MD (USA)

Some carbohydrates (CHO), e.g., fructose or sucrose but not starch, are known to aggravate the consequences of dietary Cu deficiency in rats. To evaluate if this Cu x CHO interaction is relevant to human health, the pig was used as an animal model. In the first experiment, weanling pigs (21 days of age, n=36) were fed dried skim milk (DSM)-based diets for 10 weeks with 20% of the total calories provided as either cornstarch (ST), fructose (F), or glucose (GL) and containing either deficient (-Cu; 1.4 ppm) or adequate (+Cu; 7 ppm) Cu. Plasma and tissue levels of Cu, plasma ceruloplasmin oxidase activity, activity of Cu, Zn-SOD in liver and erythrocytes, and hematocrits were lower in animals fed -Cu diets. The relative cardiac mass of all -Cu groups was greater than that of animals fed +Cu diets. These effects were not influenced by type of CHO. Similar results were obtained in a second experiment with weanling pigs (n=33) when the GL diets were excluded. For comparison, weaned male rats were also fed the same ST or F diets as pigs for as long as 10 weeks. Rats consuming both -Cu diets exhibited significantly lower hematocrits, decreased tissue Cu levels, and enlarged hearts. These changes were evident as early as 5 weeks. Together, these data demonstrate that (a) DSM-based diets are not suitable for delineation of Cu x CHO interactions, and (b) one or more components of DSM (possibly lactose) may exacerbate the consequences of dietary Cu deficiency.

• OSTI ID: 7190437
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (USA) Vol. 3:3; ISSN FAJOE; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COPPER
DIET
DOMESTIC ANIMALS
ELEMENTS
ENZYME ACTIVITY
FRUCTOSE
HEART
HEXOSES
HYPERTROPHY
KETONES
KINETICS
MAMMALS
METALS
MONOSACCHARIDES
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
POLYSACCHARIDES
RATS
REACTION KINETICS
REAGENTS
RODENTS
SACCHARIDES
STARCH
SWINE
TRANSITION ELEMENTS
VERTEBRATES