Uptake of radiolabeled copper by the liver as affected by fructose or glucose

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5450416

Fields, M; Lewis, C; Smith, J C; Reiser, S

The present investigation was designed to study liver uptake of /sup 67/Cu when administered directly into the portal vein with either fructose (Fr) or glucose (GL). Following weaning, male Sprague-Dawley rats, were fed either commercial laboratory ration (chow) or semipurified diets containing 62% carbohydrate as either (Fr) or cornstarch (St) deficient in copper (CuD) (0.6 ppm) or supplemented (CuS) (6.0 ppm) for 3 weeks. After an overnight fast, a single dose of rat plasma (0.1 ml) containing Fr or GL extrinsically labeled with /sup 67/Cu was injected directly into their portal vein. Although not always statistically significant, rats fed chow retained more radioactivity in the liver and several extrahepatic tissues when /sup 67/Cu was administered with Fr than with GL. Regardless of Cu status, rats fed diets containing Fr retained more radioactivity in extrahepatic tissues than rats fed St. The combination of Fr with /sup 67/Cu resulted in an additional uptake of the isotope by the liver, blood, muscle and fat pad when compared with GL. These data in conjunction with our previous studies where the isotope was administered i.p. strongly suggest that Cu requirements or utilization are greater when Fr is the main dietary carbohydrate. Also the results may in part explain the reasons for the increased severity of Cu deficiency in rats fed Fr.

• Research Organization: Dept. of Agriculture, Beltsville, MD
• OSTI ID: 5450416
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARBOHYDRATES
CONNECTIVE TISSUE CELLS
COPPER
COPPER 67
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIET
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
FAT CELLS
FRUCTOSE
GLANDS
GLUCOSE
HEXOSES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
METALS
MONOSACCHARIDES
MUSCLES
NUCLEI
NUTRITIONAL DEFICIENCY
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RATS
RODENTS
SACCHARIDES
SOMATIC CELLS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES