Uptake of radiolabeled copper by the liver as affected by fructose or glucose
The present investigation was designed to study liver uptake of /sup 67/Cu when administered directly into the portal vein with either fructose (Fr) or glucose (GL). Following weaning, male Sprague-Dawley rats, were fed either commercial laboratory ration (chow) or semipurified diets containing 62% carbohydrate as either (Fr) or cornstarch (St) deficient in copper (CuD) (0.6 ppm) or supplemented (CuS) (6.0 ppm) for 3 weeks. After an overnight fast, a single dose of rat plasma (0.1 ml) containing Fr or GL extrinsically labeled with /sup 67/Cu was injected directly into their portal vein. Although not always statistically significant, rats fed chow retained more radioactivity in the liver and several extrahepatic tissues when /sup 67/Cu was administered with Fr than with GL. Regardless of Cu status, rats fed diets containing Fr retained more radioactivity in extrahepatic tissues than rats fed St. The combination of Fr with /sup 67/Cu resulted in an additional uptake of the isotope by the liver, blood, muscle and fat pad when compared with GL. These data in conjunction with our previous studies where the isotope was administered i.p. strongly suggest that Cu requirements or utilization are greater when Fr is the main dietary carbohydrate. Also the results may in part explain the reasons for the increased severity of Cu deficiency in rats fed Fr.
- Research Organization:
- Dept. of Agriculture, Beltsville, MD
- OSTI ID:
- 5450416
- Report Number(s):
- CONF-8604222-; TRN: 86-028403
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
COPPER
NUTRITIONAL DEFICIENCY
TISSUE DISTRIBUTION
FRUCTOSE
BIOLOGICAL EFFECTS
GLUCOSE
BLOOD
COPPER 67
DIET
FAT CELLS
LABELLED COMPOUNDS
LIVER
MUSCLES
RATS
TRACER TECHNIQUES
UPTAKE
ALDEHYDES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOHYDRATES
CONNECTIVE TISSUE CELLS
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
GLANDS
HEXOSES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
MAMMALS
MATERIALS
METALS
MONOSACCHARIDES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RODENTS
SACCHARIDES
SOMATIC CELLS
TRANSITION ELEMENTS
VERTEBRATES
550501* - Metabolism- Tracer Techniques