Metabolic effects of carbohydrate-copper interactions in swine

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5381865

Scholfield, D J; Reiser, S; Steele, N; Darcey, S; Richards, M; Fields, M; Smith, J C

Inadequate dietary copper(Cu) is known to elicit several undesirable metabolic changes in humans and rats. Abnormal cardiac function, including sudden death is a common finding in copper deficient (CuD) rats, especially those fed diets with a high fructose (FR) content. Swine were chosen as the animal model for this project since their circulatory system is morphologically similar to that of humans. In an effort to further study these dietary effects 12 male and 12 female swine were randomly assigned to 4 groups of 6 pigs each and fed CuD and Cu supplemented (CuS) diets with 20% of calories from either FR or glucose (GL) for a period of 10 weeks. In agreement with data from recent experiments, CuD swine exhibited anemia, decreased ceruloplasmin, Cu-Zn superoxide dismutase and serum Cu; however, serum cholesterol and triglycerides decreased significantly when the animals were fed the CuD diets as compared to those fed CuS diets. Serum glutamic pyruvic transaminase (SGPT) activity was lowest for pigs fed the CuD FR diet compared to the CuS and CuD Gl groups during the study. SGPT activity usually increases when humans consume high FR diets. The results of these analyses indicate that swine are an acceptable model for the study of dietary CuD, although some indices give inverse results compared to those seen in rats and humans.

• Research Organization: Dept. of Agriculture, Beltsville, MD
• OSTI ID: 5381865
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
AMINOTRANSFERASES
ANEMIAS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
CARBOHYDRATES
CHOLESTEROL
COPPER
DIET
DISEASES
DOMESTIC ANIMALS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
ESTERS
FRUCTOSE
GLUCOSE
HEMIC DISEASES
HEXOSES
HYDROXY COMPOUNDS
KETONES
LIPIDS
MAMMALS
METABOLISM
METALS
MONOSACCHARIDES
NITROGEN TRANSFERASES
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
OXIDOREDUCTASES
SACCHARIDES
STEROIDS
STEROLS
SUPEROXIDE DISMUTASE
SWINE
SYMPTOMS
SYNERGISM
TRANSFERASES
TRANSITION ELEMENTS
TRIGLYCERIDES
VERTEBRATES