Copper-carbohydrate interaction in the pig: effects on lysyl oxidase activities (LOA)

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5492974

Ono, K; Steele, N; Richards, M; Darcey, S; Fields, M; Scholfield, D; Smith, J; Reiser, S

Fructose (FR) has been reported to aggravate copper (Cu) deficiency disorders in the rat. Weanling pigs, 21 days of age, were fed diets containing FR or glucose monohydrate (GL), each providing 20% of total calories. Diets were either unsupplemented (-, 1.5 ppm) or fortified (+, 40 ppm) with Cu. Following 10 weeks of dietary treatment, plasma and aortic LOA were appraised. Dietary Cu deficiency reduced LOA in both plasma and aortic tissue. Furthermore, feeding FR in conjunction with low Cu intake resulted in a greater reduction of aortic tissue LOA, implying that connective tissue metabolism and cardiac muscle integrity could be affected adversely. In that these effects were noted at a modest level of dietary FR, this pig model may be useful for the study of copper-carbohydrate interactions as relevant to the human population.

• Research Organization: Dept. of Agriculture, Beltsville MD
• OSTI ID: 5492974
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
CARBOHYDRATES
COPPER
DIET
DOMESTIC ANIMALS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
FRUCTOSE
GLUCOSE
HEXOSES
KETONES
MAMMALS
METABOLISM
METALS
MONOSACCHARIDES
MUSCLES
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
OXIDOREDUCTASES
SACCHARIDES
SWINE
TRANSITION ELEMENTS
VERTEBRATES