The effect of age and length of feeding on the expression of the fructose-copper interaction

Conference · Mon Mar 11 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5264721

Lewis, C G; Fields, M; Beal, T ^[1]

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1. Dept. of Agriculture, Beltsville, MD (United States) Georgetown Univ., Washington, DC (United States) Univ. of Maryland, College Park (United States)

Weanling male rats were assigned to either a fructose diet adequate in Cu (Fru+Cu) or a starch diet inadequate in Cu (St{minus}Cu) for either 1,2 or 3 wks. They were then transferred to a Fru{minus}Cu diet for the remainder of the experiment. At wk 10, body weight and relative heart size of rats initially consuming Fru+Cu was inversely related to the week placed on Fru{minus}Cu, but not for those consuming St{minus}Cu. Hematocrit, hepatic Cu concentration and erythrocyte superoxide dismutase activity were significantly lower in rats initially consuming St{minus}Cu as compared to those fed Fru+Cu. Mortality was greatest in rats switched to the Fru{minus}Cu diet at wks 1 and 2 and least in those switched at wk 3 regardless of the diet initially consumed. Plasma cholesterol, triglycerides and blood urea nitrogen concentrations were not altered by the type of diet initially consumed or by the time that the rats were switched to the Fru{minus}Cu diet. The authors conclude that while switching rats to the Fru{minus}Cu diet at 1, 2 or 3 wks after weaning did not significantly improve some of the signs associated with Cu deficiency, it did improve survival.

• OSTI ID: 5264721
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:4
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COUNT
BODY
BODY FLUIDS
CARBOHYDRATES
COPPER
DIET
DIGESTIVE SYSTEM
ELEMENTS
ENZYME ACTIVITY
ENZYMES
ERYTHROCYTES
FRUCTOSE
GLANDS
HEXOSES
KETONES
KINETICS
LIVER
MAMMALS
MATERIALS
METABOLISM
METALS
MONOSACCHARIDES
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PROTEINS
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
SUPEROXIDE DISMUTASE
TRANSITION ELEMENTS
VERTEBRATES