Ultraviolet irradiation of platelet concentrate abrogates lymphocyte activation without affecting platelet function in vitro

Journal Article · Fri Nov 01 00:00:00 EST 1985 · Transfusion (Philadelphia); (United States)

DOI:https://doi.org/10.1046/j.1537-2995.1985.25686071428.x· OSTI ID:5686558

Kahn, R A; Duffy, B F; Rodey, G G

We studied the effect of ultraviolet (UV) radiation on platelet concentrates. Samples irradiated at 310 mm for 30 minutes at a dose of 1782 J per m2 showed no loss of platelet function in vitro as determined by adenosine diphosphate, collagen, or ristocetin-induced aggregation. Lymphocytes isolated from irradiated units were unable to act as responders or stimulators in a mixed-lymphocyte reaction. These data suggest that UV radiation of platelet concentrates may result in a cell suspension that is unable to evoke an immunological response.

• OSTI ID: 5686558
• Journal Information: Transfusion (Philadelphia); (United States), Vol. 6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD PLATELETS
IRRADIATION
LYMPHOCYTES
BIOLOGICAL RADIATION EFFECTS
ADP
COLLAGEN
IN VITRO
TRANSFUSIONS
ULTRAVIOLET RADIATION
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
LEUKOCYTES
MATERIALS
NUCLEOTIDES
ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIATIONS
SCLEROPROTEINS
SOMATIC CELLS
THERAPY
560121* - Radiation Effects on Cells- External Source- (-1987)