Functional aspects of blood platelets in irradiated burros

Journal Article · Tue Feb 01 04:00:00 EST 1977 · Am. J. Vet. Res.; (United States)

OSTI ID:5732730

Schneider, M D

In irradiated burros (Equus asinus), a delayed clinical syndrome characterized by a depletion of megakarocytes and platelets has been observed. To clarify the cause of this syndrome, the functional abilities of platelets in 7 irradiated and 3 control burros were studied in vitro. The irradiated burros were survivors (> 18 years) of total-body exposures to near-lethal doses of ..gamma..-radiation. Burro platelet aggregability induced with adenosine diphosphate and thrombin, and with a complex stimulator from burro aortas, was determined by means of a self-calibrating aggregometer. Data indicated that the aggregation responsiveness to adenosine diphosphate and thrombin of platelets from surviving irradiated and unirradiated burros is not defective. An extractible collagen-like stimulator of platelet aggregation was discovered in the aorta of a burro that had survived > 24 years after exposure to a total-body dose of 545 roentgens (R) of tantalum-182 ..gamma..-radiation. The platelet-aggregating ability of this stimulator from the vessel wall of the irradiated burro was nearly fourfold greater than that from the aorta of an unirradiated control. Perhaps a delayed radiation effect could be the cause of this vascular agent's high platelet-aggregating ability and could lead to a clinical syndrome marked by depletion of megakaryocytes and platelets.

• Research Organization: Comparative Animal Research Lab., Oak Ridge, TN
• OSTI ID: 5732730
• Journal Information: Am. J. Vet. Res.; (United States), Journal Name: Am. J. Vet. Res.; (United States) Vol. 38:2; ISSN AJVRA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADP
AGGLOMERATION
ANIMALS
AORTA
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY FLUIDS
BURROS
CARDIOVASCULAR SYSTEM
COLLAGEN
DAYS LIVING RADIOISOTOPES
DELAYED RADIATION EFFECTS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
ENZYMES
ETIOLOGY
GAMMA RADIATION
HEAVY NUCLEI
HEMIC DISEASES
HYDROLASES
IN VITRO
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PROTEINS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
SCLEROPROTEINS
SYMPTOMS
TANTALUM 182
TANTALUM ISOTOPES
THROMBIN
VERTEBRATES