Simulation studies of a full-ring, CZT SPECT system for whole-body imaging of 99mTc and 177Lu
Abstract
Single photon emission computed tomography (SPECT) is an imaging modality that has demonstrated its utility in a number of clinical indications. Despite this progress, a high sensitivity, high spatial resolution, multi-tracer SPECT with a large field of view suitable for whole-body imaging of a broad range of radiotracers for theranostics is not available. With the goal of filling this technological gap, we have designed a cadmium zinc telluride (CZT) full-ring SPECT scanner instrumented with a broad-energy tungsten collimator. The final purpose is to provide a multi-tracer solution for brain and whole-body imaging. Our static SPECT does not rely on the dual- and the triple-head rotational SPECT standard paradigm, enabling a larger effective area in each scan to increase the sensitivity. We provide a demonstration of the performance of our design using a realistic model of our detector with simulated body-sized phantoms filled with 99mTc and 177Lu. Our SPECT design can resolve 7.9 mm rods for 99mTc (140 keV) and 9.5 mm for 177Lu (208 keV) in a hot-rod Derenzo phantom with a 3-min exposure and reach an image contrast of 78% for 99mTc and 57% for 177Lu using the NEMA IQ phantom with a 6-min exposure. Our modified scatter correctionmore »
- Authors:
-
- University of California, San Francisco, CA (United States)
- University Health Network, Toronto, ON (Canada)
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Shanghai Jiao Tong University (China)
- University of California, San Francisco, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- University of California, San Francisco, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); University of California, Berkeley, CA (United States)
- Publication Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Nuclear Physics (NP); National Institutes of Health (NIH)
- OSTI Identifier:
- 2204143
- Report Number(s):
- BNL-224940-2023-JAAM
Journal ID: ISSN 0094-2405
- Grant/Contract Number:
- SC0012704; R01EB026331; R01EB012965; R01HL135490
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Medical Physics
- Additional Journal Information:
- Journal Volume: 50; Journal Issue: 6; Journal ID: ISSN 0094-2405
- Publisher:
- American Association of Physicists in Medicine
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 73 NUCLEAR PHYSICS AND RADIATION PHYSICS; SPECT; CZT; full-ring; Monte Carlo simulation; finite element method
Citation Formats
Huh, Yoonsuk, Caravaca, Javier, Kim, Jaehyuk, Cui, Yonggang, Huang, Qiu, Gullberg, Grant, and Seo, Youngho. Simulation studies of a full-ring, CZT SPECT system for whole-body imaging of 99mTc and 177Lu. United States: N. p., 2023.
Web. doi:10.1002/mp.16360.
Huh, Yoonsuk, Caravaca, Javier, Kim, Jaehyuk, Cui, Yonggang, Huang, Qiu, Gullberg, Grant, & Seo, Youngho. Simulation studies of a full-ring, CZT SPECT system for whole-body imaging of 99mTc and 177Lu. United States. https://doi.org/10.1002/mp.16360
Huh, Yoonsuk, Caravaca, Javier, Kim, Jaehyuk, Cui, Yonggang, Huang, Qiu, Gullberg, Grant, and Seo, Youngho. Tue .
"Simulation studies of a full-ring, CZT SPECT system for whole-body imaging of 99mTc and 177Lu". United States. https://doi.org/10.1002/mp.16360. https://www.osti.gov/servlets/purl/2204143.
@article{osti_2204143,
title = {Simulation studies of a full-ring, CZT SPECT system for whole-body imaging of 99mTc and 177Lu},
author = {Huh, Yoonsuk and Caravaca, Javier and Kim, Jaehyuk and Cui, Yonggang and Huang, Qiu and Gullberg, Grant and Seo, Youngho},
abstractNote = {Single photon emission computed tomography (SPECT) is an imaging modality that has demonstrated its utility in a number of clinical indications. Despite this progress, a high sensitivity, high spatial resolution, multi-tracer SPECT with a large field of view suitable for whole-body imaging of a broad range of radiotracers for theranostics is not available. With the goal of filling this technological gap, we have designed a cadmium zinc telluride (CZT) full-ring SPECT scanner instrumented with a broad-energy tungsten collimator. The final purpose is to provide a multi-tracer solution for brain and whole-body imaging. Our static SPECT does not rely on the dual- and the triple-head rotational SPECT standard paradigm, enabling a larger effective area in each scan to increase the sensitivity. We provide a demonstration of the performance of our design using a realistic model of our detector with simulated body-sized phantoms filled with 99mTc and 177Lu. Our SPECT design can resolve 7.9 mm rods for 99mTc (140 keV) and 9.5 mm for 177Lu (208 keV) in a hot-rod Derenzo phantom with a 3-min exposure and reach an image contrast of 78% for 99mTc and 57% for 177Lu using the NEMA IQ phantom with a 6-min exposure. Our modified scatter correction shows an improved contrast-recovery ratio compared to a standard correction. In this paper, we demonstrate the good performance of our design for whole-body imaging purposes. This adds to our previous demonstration of improved qualitative and quantitative 99mTc imaging of brain perfusion and 123I imaging of dopamine transport with respect to state-of-the-art NaI dual-head cameras. We show that our design provides similar IQ and contrast to the commercial full-ring SPECT VERITON for 99mTc. Regarding 177Lu imaging of the 208 keV emissions, our design provides similar contrast to that of other state-of-the-art SPECTs with a significant reduction in exposure. In conclusion, the high sensitivity and extended energy range up to 250 keV makes our SPECT design a promising alternative for clinical imaging and theranostics of emerging radionuclides.},
doi = {10.1002/mp.16360},
journal = {Medical Physics},
number = 6,
volume = 50,
place = {United States},
year = {Tue Mar 14 00:00:00 EDT 2023},
month = {Tue Mar 14 00:00:00 EDT 2023}
}
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