Applications of “Tender” Energy (1-5 keV) X-ray Absorption Spectroscopy in Life Sciences

Northrup, Paul; Leri, Alessandra; Tappero, Ryan

doi:10.2174/0929866523666160107114505

Title: Applications of “Tender” Energy (1-5 keV) X-ray Absorption Spectroscopy in Life Sciences

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Abstract

The “tender” energy range of 1 to 5 keV, between the energy ranges of most “hard” (>5 keV) and “soft” (<1 keV) synchrotron X-ray facilities, offers some unique opportunities for synchrotron- based X-ray absorption fine structure spectroscopy in life sciences. In particular the K absorption edges of Na through Ca offer opportunities to study local structure, speciation, and chemistry of many important biological compounds, structures and processes. This is an area of largely untapped science, in part due to a scarcity of optimized facilities. Such measurements also entail unique experimental challenges. Here, this brief review describes the technique, its experimental challenges, recent progress in development of microbeam measurement capabilities, and several highlights illustrating applications in life sciences.

Authors:

Northrup, Paul ^[1]; Leri, Alessandra ^[2]; Tappero, Ryan ^[3]

Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II); Stony Brook Univ., NY (United States). Dept. of Geosciences
Marymount Manhattan College, New York, NY (United States). Dept. of Natural Sciences
Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II)

Publication Date:: Mon Feb 15 00:00:00 EST 2016

Research Org.:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI Identifier:: 1340387

Alternate Identifier(s):: OSTI ID: 1341507

Report Number(s):: BNL-112578-2016-JA; BNL-108478-2015-JA
Journal ID: ISSN 0929-8665

Grant/Contract Number:: SC0012704; SC00112704

Resource Type:: Accepted Manuscript

Journal Name:: Protein and Peptide Letters

Additional Journal Information:: Journal Volume: 23; Journal Issue: 3; Journal ID: ISSN 0929-8665

Publisher:: Bentham Science Publishers

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; Calcium; EXAFS; microbeam; natural organochlorine; sulfur; tender-energy; XANES; X-ray absorption spectroscopy; X-ray spectromicroscopy; 36 MATERIALS SCIENCE; calcium

Citation Formats


                    Northrup, Paul, Leri, Alessandra, and Tappero, Ryan. Applications of “Tender” Energy (1-5 keV) X-ray Absorption Spectroscopy in Life Sciences.  United States: N. p., 2016. 
Web.  doi:10.2174/0929866523666160107114505.

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                    Northrup, Paul, Leri, Alessandra, & Tappero, Ryan. Applications of “Tender” Energy (1-5 keV) X-ray Absorption Spectroscopy in Life Sciences.  United States.  https://doi.org/10.2174/0929866523666160107114505

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                    Northrup, Paul, Leri, Alessandra, and Tappero, Ryan. Mon .  
"Applications of “Tender” Energy (1-5 keV) X-ray Absorption Spectroscopy in Life Sciences".  United States.  https://doi.org/10.2174/0929866523666160107114505.  https://www.osti.gov/servlets/purl/1340387.

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@article{osti_1340387,

  title        = {Applications of “Tender” Energy (1-5 keV) X-ray Absorption Spectroscopy in Life Sciences},

  author       = {Northrup, Paul and Leri, Alessandra and Tappero, Ryan},

  abstractNote = {The “tender” energy range of 1 to 5 keV, between the energy ranges of most “hard” (>5 keV) and “soft” (<1 keV) synchrotron X-ray facilities, offers some unique opportunities for synchrotron- based X-ray absorption fine structure spectroscopy in life sciences. In particular the K absorption edges of Na through Ca offer opportunities to study local structure, speciation, and chemistry of many important biological compounds, structures and processes. This is an area of largely untapped science, in part due to a scarcity of optimized facilities. Such measurements also entail unique experimental challenges. Here, this brief review describes the technique, its experimental challenges, recent progress in development of microbeam measurement capabilities, and several highlights illustrating applications in life sciences.},

  doi          = {10.2174/0929866523666160107114505},

  journal      = {Protein and Peptide Letters},

  number       = 3,

  volume       = 23,

  place        = {United States},

  year         = {Mon Feb 15 00:00:00 EST 2016},

  month        = {Mon Feb 15 00:00:00 EST 2016}

}

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