Nanoporous silica-based protocells at multiple scales for designs of life and nanomedicine
Abstract
In this study, various protocell models have been constructed de novo with the bottom-up approach. Here we describe a silica-based protocell composed of a nanoporous amorphous silica core encapsulated within a lipid bilayer built by self-assembly that provides for independent definition of cell interior and the surface membrane. In this review, we will first describe the essential features of this architecture and then summarize the current development of silica-based protocells at both micro- and nanoscale with diverse functionalities. As the structure of the silica is relatively static, silica-core protocells do not have the ability to change shape, but their interior structure provides a highly crowded and, in some cases, authentic scaffold upon which biomolecular components and systems could be reconstituted. In basic research, the larger protocells based on precise silica replicas of cells could be developed into geometrically realistic bioreactor platforms to enable cellular functions like coupled biochemical reactions, while in translational research smaller protocells based on mesoporous silica nanoparticles are being developed for targeted nanomedicine. Ultimately we see two different motivations for protocell research and development: (1) to emulate life in order to understand it; and (2) to use biomimicry to engineer desired cellular interactions.
- Authors:
-
- Univ. of Illinois, Urbana, IL (United States)
- Univ. of California San Diego, La Jolla, CA (United States)
- Univ. of New Mexico, Albuquerque, NM (United States); Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Publication Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- National Science Foundation (NSF), Arlington, VA (United States)
- OSTI Identifier:
- 1237664
- Report Number(s):
- SAND-2015-5323J
Journal ID: ISSN 2075-1729; LBSIB7; PII: life5010214
- Grant/Contract Number:
- AC04-94AL85000
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Life
- Additional Journal Information:
- Journal Volume: 5; Journal Issue: 1; Journal ID: ISSN 2075-1729
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY; protocell; nanoporous silica; synthetic biology; supported lipid bilayer; FRET; nanomedicine; designs of life
Citation Formats
Sun, Jie, Jakobsson, Eric, Wang, Yingxiao, and Brinker, C. Jeffrey. Nanoporous silica-based protocells at multiple scales for designs of life and nanomedicine. United States: N. p., 2015.
Web. doi:10.3390/life5010214.
Sun, Jie, Jakobsson, Eric, Wang, Yingxiao, & Brinker, C. Jeffrey. Nanoporous silica-based protocells at multiple scales for designs of life and nanomedicine. United States. https://doi.org/10.3390/life5010214
Sun, Jie, Jakobsson, Eric, Wang, Yingxiao, and Brinker, C. Jeffrey. Mon .
"Nanoporous silica-based protocells at multiple scales for designs of life and nanomedicine". United States. https://doi.org/10.3390/life5010214. https://www.osti.gov/servlets/purl/1237664.
@article{osti_1237664,
title = {Nanoporous silica-based protocells at multiple scales for designs of life and nanomedicine},
author = {Sun, Jie and Jakobsson, Eric and Wang, Yingxiao and Brinker, C. Jeffrey},
abstractNote = {In this study, various protocell models have been constructed de novo with the bottom-up approach. Here we describe a silica-based protocell composed of a nanoporous amorphous silica core encapsulated within a lipid bilayer built by self-assembly that provides for independent definition of cell interior and the surface membrane. In this review, we will first describe the essential features of this architecture and then summarize the current development of silica-based protocells at both micro- and nanoscale with diverse functionalities. As the structure of the silica is relatively static, silica-core protocells do not have the ability to change shape, but their interior structure provides a highly crowded and, in some cases, authentic scaffold upon which biomolecular components and systems could be reconstituted. In basic research, the larger protocells based on precise silica replicas of cells could be developed into geometrically realistic bioreactor platforms to enable cellular functions like coupled biochemical reactions, while in translational research smaller protocells based on mesoporous silica nanoparticles are being developed for targeted nanomedicine. Ultimately we see two different motivations for protocell research and development: (1) to emulate life in order to understand it; and (2) to use biomimicry to engineer desired cellular interactions.},
doi = {10.3390/life5010214},
journal = {Life},
number = 1,
volume = 5,
place = {United States},
year = {Mon Jan 19 00:00:00 EST 2015},
month = {Mon Jan 19 00:00:00 EST 2015}
}
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A Membrane-Reconstituted Multisubunit Functional Proton Pump on Mesoporous Silica Particles
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Join the crowd
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Electrostatically gated membrane permeability in inorganic protocells
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Fatty acid membrane assembly on coacervate microdroplets as a step towards a hybrid protocell model
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Interfacial assembly of protein–polymer nano-conjugates into stimulus-responsive biomimetic protocells
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The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers
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Compartmentalized reactions as a case of soft-matter biotechnology: synthesis of proteins and nucleic acids inside lipid vesicles
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Recent Biophysical Issues About the Preparation of Solute-Filled Lipid Vesicles
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Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles
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Supported Membranes: Scientific and Practical Applications
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NOONAN SYNDROME AND RELATED DISORDERS: Genetics and Pathogenesis
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Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis
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