Toroidal mesoporous silica nanoparticles (TMSNPs) and related protocells

Brinker, C. Jeffrey; Lin, Yu-Shen

Title: Toroidal mesoporous silica nanoparticles (TMSNPs) and related protocells

Patent · Tue Jan 02 00:00:00 EST 2018

OSTI ID:1415623

Brinker, C. Jeffrey; Lin, Yu-Shen

In one aspect, the invention provides novel monodisperse, colloidally-stable, toroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia basecatalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

View Patent

Cite

Export

Save

Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: STC. UNM (Albuquerque, NM); National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)

Patent Number(s):: 9,855,217

Application Number:: 15/023,110

OSTI ID:: 1415623

Resource Relation:: Patent File Date: 2014 Sep 18

Country of Publication:: United States

Language:: English

References (9)

Control of the morphology of nanostructured particles prepared by the spray drying of a nanoparticle sol Iskandar, Ferry; Gradon, Leon; Okuyama, Kikuo Journal of Colloid and Interface Science, Vol. 265, Issue 2, p. 296-303 https://doi.org/10.1016/S0021-9797(03)00519-8	journal	September 2003
Surfactant Control of Phases in the Synthesis of Mesoporous Silica-Based Materials Huo, Qisheng; Margolese, David I.; Stucky, Galen D. Chemistry of Materials, Vol. 8, Issue 5 https://doi.org/10.1021/cm960137h	journal	January 1996
Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord Dengler, Ellen C.; Liu, Juewen; Kerwin, Audra Journal of Controlled Release, Vol. 168, Issue 2, p. 209-224 https://doi.org/10.1016/j.jconrel.2013.03.009	journal	June 2013
Template-Free Formation of Monodisperse Doughnut-Shaped Silica Microparticles by Droplet-Based Microfluidics Fang, Aiping; Gaillard, Cédric; Douliez, Jean-Paul Chemistry of Materials, Vol. 23, Issue 21, p. 4660-4662 https://doi.org/10.1021/cm202145s	journal	November 2011
Synthesis and Formation Mechanism of Aminated Mesoporous Silica Nanoparticles Suteewong, Teeraporn; Sai, Hiroaki; Bradbury, Michelle Chemistry of Materials, Vol. 24, Issue 20, p. 3895-3905 https://doi.org/10.1021/cm301857e	journal	October 2012
Synthesis of Mesoporous Silica Particles and Capsules by Miniemulsion Technique Schiller, Renate; Weiss, Clemens K.; Geserick, Jasmin Chemistry of Materials, Vol. 21, Issue 21 https://doi.org/10.1021/cm901858v	journal	November 2009
Liquid-crystalline phases as templates for the synthesis of mesoporous silica Attard, George S.; Glyde, Joanna C.; Göltner, Christine G. Nature, Vol. 378, Issue 6555, p. 366-368 https://doi.org/10.1038/378366a0	journal	November 1995
Control of Pore Sizes in Mesoporous Silica Templated by Liquid Crystals in Block Copolymer−Cosurfactant−Water Systems Feng, Pingyun; Bu, Xianhui; Pine, David J. Langmuir, Vol. 16, Issue 12, p. 5304-5310 https://doi.org/10.1021/la991444f	journal	June 2000
Toroidal microporous silica gel Zapryanova, A.; Trendafelov, D.; Mehandjiev, D. Journal of Materials Science, Vol. 14, Issue 5, p. 1175-1178 https://doi.org/10.1007/BF00561302	journal	May 1979

Similar Records

Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells

Journal Article · Fri Jul 15 00:00:00 EDT 2016 · ACS Nano · OSTI ID:1415623

Durfee, Paul N.; Lin, Yu-Shen; Dunphy, Darren R.; +11 more

Medium controlled aggregative growth as a key step in mesoporous silica nanoparticle formation

Journal Article · Mon Jan 31 00:00:00 EST 2022 · Journal of Colloid and Interface Science · OSTI ID:1415623

Semeykina, Viktoriya; Zharov, Ilya

Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same

Patent · Tue Feb 28 00:00:00 EST 2017 · OSTI ID:1415623

Brinker, C. Jeffrey; Carnes, Eric C.; Ashley, Carlee Erin; +1 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES

Title: Toroidal mesoporous silica nanoparticles (TMSNPs) and related protocells

Citation Formats

References (9)

Similar Records

Related Subjects