Strategies for Controlling the Spatial Orientation of Single Molecules Tethered on DNA Origami Templates Physisorbed on Glass Substrates: Intercalation and Stretching
Abstract
Nanoarchitectural control of matter is crucial for next-generation technologies. DNA origami templates are harnessed to accurately position single molecules; however, direct single molecule evidence is lacking regarding how well DNA origami can control the orientation of such molecules in three-dimensional space, as well as the factors affecting control. Here, we present two strategies for controlling the polar (θ) and in-plane azimuthal (Φ) angular orientations of cyanine Cy5 single molecules tethered on rationally-designed DNA origami templates that are physically adsorbed (physisorbed) on glass substrates. By using dipolar imaging to evaluate Cy5's orientation and super-resolution microscopy, the absolute spatial orientation of Cy5 is calculated relative to the DNA template. The sequence-dependent partial intercalation of Cy5 is discovered and supported theoretically using density functional theory and molecular dynamics simulations, and it is harnessed as our first strategy to achieve θ control for a full revolution with dispersion as small as ±4.5°. In our second strategy, Φ control is achieved by mechanically stretching the Cy5 from its two tethers, being the dispersion ±10.3° for full stretching. These results can in principle be applied to any single molecule, expanding in this way the capabilities of DNA as a functional templating material for single-molecule orientation control.more »
- Authors:
-
[1];
[1];
[1];
[3];
[1];
[1];
[3];
- Boise State Univ., ID (United States)
- U.S. Naval Research Lab., Washington, DC (United States)
- Boise State Univ., ID (United States); Center for Advanced Energy Studies, Idaho Falls, ID (United States)
- Publication Date:
- Research Org.:
- Boise State Univ., ID (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; Department of Navy, Office of Naval Science
- OSTI Identifier:
- 1876010
- Grant/Contract Number:
- SC0020089; N00014-19-1-2615
- Resource Type:
- Accepted Manuscript
- Journal Name:
- International Journal of Molecular Sciences (Online)
- Additional Journal Information:
- Journal Name: International Journal of Molecular Sciences (Online); Journal Volume: 23; Journal Issue: 14; Journal ID: ISSN 1422-0067
- Publisher:
- MDPI
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 77 NANOSCIENCE AND NANOTECHNOLOGY; nanoarchitectural control; DNA origami; dipolar imaging; super-resolution microscopy; cyanine Cy5 dyes; dye intercalation; mechanical stretching; density function theory; molecular dynamics simulations; DNA-PAINT
Citation Formats
Cervantes-Salguero, Keitel, Biaggne, Austin, Youngsman, John M., Ward, Brett M., Kim, Young C., Li, Lan, Hall, John A., Knowlton, William B., Graugnard, Elton, and Kuang, Wan. Strategies for Controlling the Spatial Orientation of Single Molecules Tethered on DNA Origami Templates Physisorbed on Glass Substrates: Intercalation and Stretching. United States: N. p., 2022.
Web. doi:10.3390/ijms23147690.
Cervantes-Salguero, Keitel, Biaggne, Austin, Youngsman, John M., Ward, Brett M., Kim, Young C., Li, Lan, Hall, John A., Knowlton, William B., Graugnard, Elton, & Kuang, Wan. Strategies for Controlling the Spatial Orientation of Single Molecules Tethered on DNA Origami Templates Physisorbed on Glass Substrates: Intercalation and Stretching. United States. https://doi.org/10.3390/ijms23147690
Cervantes-Salguero, Keitel, Biaggne, Austin, Youngsman, John M., Ward, Brett M., Kim, Young C., Li, Lan, Hall, John A., Knowlton, William B., Graugnard, Elton, and Kuang, Wan. Tue .
"Strategies for Controlling the Spatial Orientation of Single Molecules Tethered on DNA Origami Templates Physisorbed on Glass Substrates: Intercalation and Stretching". United States. https://doi.org/10.3390/ijms23147690. https://www.osti.gov/servlets/purl/1876010.
@article{osti_1876010,
title = {Strategies for Controlling the Spatial Orientation of Single Molecules Tethered on DNA Origami Templates Physisorbed on Glass Substrates: Intercalation and Stretching},
author = {Cervantes-Salguero, Keitel and Biaggne, Austin and Youngsman, John M. and Ward, Brett M. and Kim, Young C. and Li, Lan and Hall, John A. and Knowlton, William B. and Graugnard, Elton and Kuang, Wan},
abstractNote = {Nanoarchitectural control of matter is crucial for next-generation technologies. DNA origami templates are harnessed to accurately position single molecules; however, direct single molecule evidence is lacking regarding how well DNA origami can control the orientation of such molecules in three-dimensional space, as well as the factors affecting control. Here, we present two strategies for controlling the polar (θ) and in-plane azimuthal (Φ) angular orientations of cyanine Cy5 single molecules tethered on rationally-designed DNA origami templates that are physically adsorbed (physisorbed) on glass substrates. By using dipolar imaging to evaluate Cy5's orientation and super-resolution microscopy, the absolute spatial orientation of Cy5 is calculated relative to the DNA template. The sequence-dependent partial intercalation of Cy5 is discovered and supported theoretically using density functional theory and molecular dynamics simulations, and it is harnessed as our first strategy to achieve θ control for a full revolution with dispersion as small as ±4.5°. In our second strategy, Φ control is achieved by mechanically stretching the Cy5 from its two tethers, being the dispersion ±10.3° for full stretching. These results can in principle be applied to any single molecule, expanding in this way the capabilities of DNA as a functional templating material for single-molecule orientation control. The experimental and modeling insights provided herein will help engineer similar self-assembling molecular systems based on polymers, such as RNA and proteins.},
doi = {10.3390/ijms23147690},
journal = {International Journal of Molecular Sciences (Online)},
number = 14,
volume = 23,
place = {United States},
year = {Tue Jul 12 00:00:00 EDT 2022},
month = {Tue Jul 12 00:00:00 EDT 2022}
}
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Works referenced in this record:
DNA nanotechnology
journal, November 2017
- Seeman, Nadrian C.; Sleiman, Hanadi F.
- Nature Reviews Materials, Vol. 3, Issue 1
Constructing covalent organic nanoarchitectures molecule by molecule via scanning probe manipulation
journal, September 2021
- Zhong, Qigang; Ihle, Alexander; Ahles, Sebastian
- Nature Chemistry, Vol. 13, Issue 11
Development of a Robust Model System of FRET using Base Surrogates Tethering Fluorophores for Strict Control of Their Position and Orientation within DNA Duplex
journal, January 2013
- Kato, Tomohiro; Kashida, Hiromu; Kishida, Hideo
- Journal of the American Chemical Society, Vol. 135, Issue 2
Absolute and arbitrary orientation of single-molecule shapes
journal, February 2021
- Gopinath, Ashwin; Thachuk, Chris; Mitskovets, Anya
- Science, Vol. 371, Issue 6531
Orienting an Organic Semiconductor into DNA 3D Arrays by Covalent Bonds
journal, December 2021
- Wang, Xiao; Deshmukh, Rahul; Sha, Ruojie
- Angewandte Chemie International Edition, Vol. 61, Issue 5
All-optical field-free three-dimensional orientation of asymmetric-top molecules
journal, December 2018
- Lin, Kang; Tutunnikov, Ilia; Qiang, Junjie
- Nature Communications, Vol. 9, Issue 1
How to control single-molecule rotation
journal, October 2019
- Simpson, Grant J.; García-López, Víctor; Daniel Boese, A.
- Nature Communications, Vol. 10, Issue 1
The Role of Molecular Dipole Orientation in Single-Molecule Fluorescence Microscopy and Implications for Super-Resolution Imaging
journal, December 2013
- Backlund, Mikael P.; Lew, Matthew D.; Backer, Adam S.
- ChemPhysChem, Vol. 15, Issue 4
Enhanced Light–Matter Interaction and Polariton Relaxation by the Control of Molecular Orientation
journal, September 2021
- Ishii, Tomohiro; Bencheikh, Fatima; Forget, Sébastien
- Advanced Optical Materials, Vol. 9, Issue 22
The Many Facets of Molecular Orientation in Organic Optoelectronics
journal, August 2021
- Hofmann, Alexander; Schmid, Markus; Brütting, Wolfgang
- Advanced Optical Materials, Vol. 9, Issue 21
Exploiting chemistry and molecular systems for quantum information science
journal, July 2020
- Wasielewski, Michael R.; Forbes, Malcolm D. E.; Frank, Natia L.
- Nature Reviews Chemistry, Vol. 4, Issue 9
Light Absorption and Energy Transfer in the Antenna Complexes of Photosynthetic Organisms
journal, March 2016
- Mirkovic, Tihana; Ostroumov, Evgeny E.; Anna, Jessica M.
- Chemical Reviews, Vol. 117, Issue 2
The biological applications of DNA nanomaterials: current challenges and future directions
journal, October 2021
- Ma, Wenjuan; Zhan, Yuxi; Zhang, Yuxin
- Signal Transduction and Targeted Therapy, Vol. 6, Issue 1
DNA Nanostructures: Current Challenges and Opportunities for Cellular Delivery
journal, February 2021
- Lacroix, Aurélie; Sleiman, Hanadi F.
- ACS Nano, Vol. 15, Issue 3
Single-molecule DNA origami aptasensors for real-time biomarker detection
journal, January 2020
- Cervantes-Salguero, Keitel; Freeley, Mark; Chávez, Jorge L.
- Journal of Materials Chemistry B, Vol. 8, Issue 30
DNA Origami Voltage Sensors for Transmembrane Potentials with Single-Molecule Sensitivity
journal, October 2021
- Ochmann, Sarah E.; Joshi, Himanshu; Büber, Ece
- Nano Letters, Vol. 21, Issue 20
An alternative approach to nucleic acid memory
journal, April 2021
- Dickinson, George D.; Mortuza, Golam Md; Clay, William
- Nature Communications, Vol. 12, Issue 1
DNA Origami Route for Nanophotonics
journal, February 2018
- Kuzyk, Anton; Jungmann, Ralf; Acuna, Guillermo P.
- ACS Photonics, Vol. 5, Issue 4
Progress and perspective on chiral plasmonic nanostructures enabled by DNA programming methodology
journal, January 2021
- Yang, Hao; Li, Huacheng; Tang, Pan
- Materials Advances, Vol. 2, Issue 22
Plasmon resonance tuning using DNA origami actuation
journal, January 2015
- Piantanida, Luca; Naumenko, Denys; Torelli, Emanuela
- Chemical Communications, Vol. 51, Issue 23
An All-Optical Excitonic Switch Operated in the Liquid and Solid Phases
journal, February 2019
- Kellis, Donald L.; Sarter, Christopher; Cannon, Brittany L.
- ACS Nano, Vol. 13, Issue 3
A Single Molecule Polyphenylene-Vinylene Photonic Wire
journal, May 2021
- Madsen, Mikael; Bakke, Mette R.; Gudnason, Daniel A.
- ACS Nano, Vol. 15, Issue 6
Programmed coherent coupling in a synthetic DNA-based excitonic circuit
journal, November 2017
- Boulais, Étienne; Sawaya, Nicolas P. D.; Veneziano, Rémi
- Nature Materials, Vol. 17, Issue 2
Folding DNA to create nanoscale shapes and patterns
journal, March 2006
- Rothemund, Paul W. K.
- Nature, Vol. 440, Issue 7082, p. 297-302
DNA origami
journal, January 2021
- Dey, Swarup; Fan, Chunhai; Gothelf, Kurt V.
- Nature Reviews Methods Primers, Vol. 1, Issue 1
Self-assembly of DNA into nanoscale three-dimensional shapes
journal, May 2009
- Douglas, Shawn M.; Dietz, Hendrik; Liedl, Tim
- Nature, Vol. 459, Issue 7245
Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds
journal, April 2019
- Engelhardt, Floris A. S.; Praetorius, Florian; Wachauf, Christian H.
- ACS Nano, Vol. 13, Issue 5
Developing DNA Nanotechnology Using Single-Molecule Fluorescence
journal, May 2014
- Tsukanov, Roman; Tomov, Toma E.; Liber, Miran
- Accounts of Chemical Research, Vol. 47, Issue 6
Placing molecules with Bohr radius resolution using DNA origami
journal, October 2015
- Funke, Jonas J.; Dietz, Hendrik
- Nature Nanotechnology, Vol. 11, Issue 1
Cryogenic Far-Field Fluorescence Nanoscopy: Evaluation with DNA Origami
journal, August 2020
- Furubayashi, Taku; Ishida, Keita; Nakata, Eiji
- The Journal of Physical Chemistry B, Vol. 124, Issue 35
Engineering couplings for exciton transport using synthetic DNA scaffolds
journal, March 2021
- Hart, Stephanie M.; Chen, Wei Jia; Banal, James L.
- Chem, Vol. 7, Issue 3
Dinucleotides as simple models of the base stacking-unstacking component of DNA ‘breathing’ mechanisms
journal, January 2021
- Beyerle, Eric R.; Dinpajooh, Mohammadhasan; Ji, Huiying
- Nucleic Acids Research, Vol. 49, Issue 4
Exciton Delocalization and Scaffold Stability in Bridged Nucleotide-Substituted, DNA Duplex-Templated Cyanine Aggregates
journal, December 2021
- Roy, Simon K.; Mass, Olga A.; Kellis, Donald L.
- The Journal of Physical Chemistry B, Vol. 125, Issue 50
Can a DNA Origami Structure Constrain the Position and Orientation of an Attached Dye Molecule?
journal, December 2020
- Mathur, Divita; Kim, Young C.; Díaz, Sebastián A.
- The Journal of Physical Chemistry C, Vol. 125, Issue 2
Determining the In-Plane Orientation and Binding Mode of Single Fluorescent Dyes in DNA Origami Structures
journal, March 2021
- Hübner, Kristina; Joshi, Himanshu; Aksimentiev, Aleksei
- ACS Nano, Vol. 15, Issue 3
Choice of fluorophore affects dynamic DNA nanostructures
journal, March 2021
- Jahnke, Kevin; Grubmüller, Helmut; Igaev, Maxim
- Nucleic Acids Research, Vol. 49, Issue 7
How fluorescent labels affect the kinetics of the toehold-mediated DNA strand displacement reaction
journal, January 2022
- Li, Chengxu; Li, Zhigang; Han, Wenjie
- Chemical Communications, Vol. 58, Issue 39
Accurate Distance Determination of Nucleic Acids via Förster Resonance Energy Transfer: Implications of Dye Linker Length and Rigidity
journal, March 2011
- Sindbert, Simon; Kalinin, Stanislav; Nguyen, Hien
- Journal of the American Chemical Society, Vol. 133, Issue 8
Base-Pairing and Base-Stacking Contributions to Double-Stranded DNA Formation
journal, November 2020
- Zacharias, Martin
- The Journal of Physical Chemistry B, Vol. 124, Issue 46
Nanoarchitectonics for Hybrid and Related Materials for Bio-Oriented Applications
journal, September 2017
- Ariga, Katsuhiko; Leong, David Tai; Mori, Taizo
- Advanced Functional Materials, Vol. 28, Issue 27
DNA Nanoarchitectonics: Assembled DNA at Interfaces
journal, February 2013
- Howorka, Stefan
- Langmuir, Vol. 29, Issue 24
Materialistic Interfaces with Nucleic Acids: Principles and Their Impact
journal, March 2022
- Li, Bang Lin; Zhang, Hang; Li, Nian Bing
- Advanced Functional Materials
Orientation dependence in fluorescent energy transfer between Cy3 and Cy5 terminally attached to double-stranded nucleic acids
journal, August 2008
- Iqbal, A.; Arslan, S.; Okumus, B.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 32
Single-pair fluorescence resonance energy transfer on freely diffusing molecules: Observation of Forster distance dependence and subpopulations
journal, March 1999
- Deniz, A. A.; Dahan, M.; Grunwell, J. R.
- Proceedings of the National Academy of Sciences, Vol. 96, Issue 7
The Structure of Cyanine 5 Terminally Attached to Double-Stranded DNA: Implications for FRET Studies
journal, July 2008
- Iqbal, Asif; Wang, Lihua; Thompson, Katherine C.
- Biochemistry, Vol. 47, Issue 30
Super-resolution orientation estimation and localization of fluorescent dipoles using 3-D steerable filters
journal, January 2009
- Aguet, Francois; Geissbühler, Stefan; Märki, Iwan
- Optics Express, Vol. 17, Issue 8
Optimized measurements of separations and angles between intra-molecular fluorescent markers
journal, October 2015
- Mortensen, Kim I.; Sung, Jongmin; Flyvbjerg, Henrik
- Nature Communications, Vol. 6, Issue 1
FRET nanoscopy enables seamless imaging of molecular assemblies with sub-nanometer resolution
preprint, January 2021
- Budde, Jan-Hendrik; van der Voort, Nicolaas; Felekyan, Suren
- arXiv
Efficient One-Step PEG-Silane Passivation of Glass Surfaces for Single-Molecule Fluorescence Studies
journal, October 2018
- Gidi, Yasser; Bayram, Serene; Ablenas, Christopher J.
- ACS Applied Materials & Interfaces, Vol. 10, Issue 46
Correlative Super-Resolution and Atomic Force Microscopy of DNA Nanostructures and Characterization of Addressable Site Defects
journal, June 2021
- Green, Christopher M.; Hughes, William L.; Graugnard, Elton
- ACS Nano, Vol. 15, Issue 7
Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing
journal, March 2019
- Wang, Shangfeng; Fan, Yong; Li, Dandan
- Nature Communications, Vol. 10, Issue 1
Defining the Basis of Cyanine Phototruncation Enables a New Approach to Single-Molecule Localization Microscopy
journal, June 2021
- Matikonda, Siddharth S.; Helmerich, Dominic A.; Meub, Mara
- ACS Central Science, Vol. 7, Issue 7
Doping Evolution and Junction Formation in Stacked Cyanine Dye Light-Emitting Electrochemical Cells
journal, March 2016
- Jenatsch, Sandra; Wang, Lei; Bulloni, Matia
- ACS Applied Materials & Interfaces, Vol. 8, Issue 10
The Fisher-Bingham Distribution on the Sphere
journal, September 1982
- Kent, John T.
- Journal of the Royal Statistical Society: Series B (Methodological), Vol. 44, Issue 1
Methods for spherical data analysis and visualization
journal, April 1998
- Leong, Philip; Carlile, Simon
- Journal of Neuroscience Methods, Vol. 80, Issue 2
DNA sequence-dependent deformability deduced from protein-DNA crystal complexes
journal, September 1998
- Olson, W. K.; Gorin, A. A.; Lu, X. -J.
- Proceedings of the National Academy of Sciences, Vol. 95, Issue 19
Probing Transient DNA Conformation Changes with an Intercalative Fluorescent Excimer
journal, February 2021
- Chen, Bin; Huang, Qiuling; Qu, Zhibei
- Angewandte Chemie International Edition, Vol. 60, Issue 12
Photophysical and Dynamical Properties of Doubly Linked Cy3–DNA Constructs
journal, December 2013
- Stennett, Elana M. S.; Ma, Ning; van der Vaart, Arjan
- The Journal of Physical Chemistry B, Vol. 118, Issue 1
Interaction of cyanine dyes with nucleic acids. XXI. Arguments for half-intercalation model of interaction
journal, January 2001
- Yarmoluk, S. M.; Lukashov, S. S.; Ogul'Chansky, T. Yu.
- Biopolymers, Vol. 62, Issue 4
A glow discharge unit to render electron microscope grids and other surfaces hydrophilic
journal, September 1987
- Aebi, Ueli; Pollard, Thomas D.
- Journal of Electron Microscopy Technique, Vol. 7, Issue 1
An order of magnitude faster DNA-PAINT imaging by optimized sequence design and buffer conditions
journal, October 2019
- Schueder, Florian; Stein, Johannes; Stehr, Florian
- Nature Methods, Vol. 16, Issue 11
ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imaging
journal, May 2014
- Ovesný, Martin; Křížek, Pavel; Borkovec, Josef
- Bioinformatics, Vol. 30, Issue 16
UCSF ChimeraX : Structure visualization for researchers, educators, and developers
journal, October 2020
- Pettersen, Eric F.; Goddard, Thomas D.; Huang, Conrad C.
- Protein Science, Vol. 30, Issue 1
Influence of the - interaction on the hydrogen bonding capacity of stacked DNA/RNA bases
journal, March 2005
- Mignon, P.
- Nucleic Acids Research, Vol. 33, Issue 6
DNA base stacking involving adenine and 2-aminopurine
journal, December 2015
- van Mourik, Tanja; Hogan, Simon W. L.
- Structural Chemistry, Vol. 27, Issue 1
An in-depth study on noncovalent stacking interactions between DNA bases and aromatic drug fragments using DFT method and AIM analysis: conformers, binding energies, and charge transfer
journal, February 2018
- Toupkanloo, Hossein Azizi; Rahmani, Zoha
- Applied Biological Chemistry, Vol. 61, Issue 2
Toward True DNA Base-Stacking Energies: MP2, CCSD(T), and Complete Basis Set Calculations
journal, October 2002
- Hobza, Pavel; Šponer, Jiří
- Journal of the American Chemical Society, Vol. 124, Issue 39
Long-range corrected hybrid density functionals with damped atom–atom dispersion corrections
journal, January 2008
- Chai, Jeng-Da; Head-Gordon, Martin
- Physical Chemistry Chemical Physics, Vol. 10, Issue 44
How does basis set superposition error change the potential surfaces for hydrogen‐bonded dimers?
journal, December 1996
- Simon, Sílvia; Duran, Miquel; Dannenberg, J. J.
- The Journal of Chemical Physics, Vol. 105, Issue 24
The calculation of small molecular interactions by the differences of separate total energies. Some procedures with reduced errors
journal, October 1970
- Boys, S.F.; Bernardi, F.
- Molecular Physics, Vol. 19, Issue 4, p. 553-566
GROMACS: Fast, flexible, and free
journal, January 2005
- Van Der Spoel, David; Lindahl, Erik; Hess, Berk
- Journal of Computational Chemistry, Vol. 26, Issue 16
Assessing the Current State of Amber Force Field Modifications for DNA
journal, July 2016
- Galindo-Murillo, Rodrigo; Robertson, James C.; Zgarbová, Marie
- Journal of Chemical Theory and Computation, Vol. 12, Issue 8
Improved Parametrization of Li + , Na + , K + , and Mg 2+ Ions for All-Atom Molecular Dynamics Simulations of Nucleic Acid Systems
journal, December 2011
- Yoo, Jejoong; Aksimentiev, Aleksei
- The Journal of Physical Chemistry Letters, Vol. 3, Issue 1
Development and testing of a general amber force field
journal, January 2004
- Wang, Junmei; Wolf, Romain M.; Caldwell, James W.
- Journal of Computational Chemistry, Vol. 25, Issue 9
A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: the RESP model
journal, October 1993
- Bayly, Christopher I.; Cieplak, Piotr; Cornell, Wendy
- The Journal of Physical Chemistry, Vol. 97, Issue 40
LINCS: A linear constraint solver for molecular simulations
journal, September 1997
- Hess, Berk; Bekker, Henk; Berendsen, Herman J. C.
- Journal of Computational Chemistry, Vol. 18, Issue 12
Canonical sampling through velocity rescaling
journal, January 2007
- Bussi, Giovanni; Donadio, Davide; Parrinello, Michele
- The Journal of Chemical Physics, Vol. 126, Issue 1
Polymorphic transitions in single crystals: A new molecular dynamics method
journal, December 1981
- Parrinello, M.; Rahman, A.
- Journal of Applied Physics, Vol. 52, Issue 12
Rotaxane rings promote oblique packing and extended lifetimes in DNA-templated molecular dye aggregates
journal, February 2021
- Barclay, Matthew S.; Roy, Simon K.; Huff, Jonathan S.
- Communications Chemistry, Vol. 4, Issue 1
Exciton Delocalization in Indolenine Squaraine Aggregates Templated by DNA Holliday Junction Scaffolds
journal, October 2020
- Mass, Olga A.; Wilson, Christopher K.; Roy, Simon K.
- The Journal of Physical Chemistry B, Vol. 124, Issue 43
Deoxyribonucleic Acid Encoded and Size-Defined π-Stacking of Perylene Diimides
journal, December 2021
- Gorman, Jeffrey; Orsborne, Sarah R. E.; Sridhar, Akshay
- Journal of the American Chemical Society, Vol. 144, Issue 1
Exciton Delocalization in a DNA-Templated Organic Semiconductor Dimer Assembly
journal, January 2022
- Wang, Xiao; Sha, Ruojie; Knowlton, William B.
- ACS Nano, Vol. 16, Issue 1
Imaging Dynamic Processes in Multiple Dimensions and Length Scales
journal, April 2022
- Filbrun, Seth L.; Zhao, Fei; Chen, Kuangcai
- Annual Review of Physical Chemistry, Vol. 73, Issue 1
Polymorphic Ring-Shaped Molecular Clusters Made of Shape-Variable Building Blocks
journal, February 2015
- Cervantes-Salguero, Keitel; Hamada, Shogo; Nomura, Shin-ichiro
- Nanomaterials, Vol. 5, Issue 1
Double‐ to Single‐Strand Transition Induces Forces and Motion in DNA Origami Nanostructures
journal, August 2021
- Gür, Fatih N.; Kempter, Susanne; Schueder, Florian
- Advanced Materials, Vol. 33, Issue 37
A self-assembled nanoscale robotic arm controlled by electric fields
journal, January 2018
- Kopperger, Enzo; List, Jonathan; Madhira, Sushi
- Science, Vol. 359, Issue 6373
Electrostatic Effect of Functional Surfaces on the Activity of Adsorbed Enzymes: Simulations and Experiments
journal, July 2020
- Zheng, He; Yang, Sheng-Jiang; Zheng, Yong-Chao
- ACS Applied Materials & Interfaces, Vol. 12, Issue 31
Graphene Energy Transfer for Single‐Molecule Biophysics, Biosensing, and Super‐Resolution Microscopy
journal, October 2021
- Kamińska, Izabela; Bohlen, Johann; Yaadav, Renukka
- Advanced Materials, Vol. 33, Issue 42
RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds
journal, May 2021
- Geary, Cody; Grossi, Guido; McRae, Ewan K. S.
- Nature Chemistry, Vol. 13, Issue 6
Designed folding pathway of modular coiled-coil-based proteins
journal, February 2021
- Aupič, Jana; Strmšek, Žiga; Lapenta, Fabio
- Nature Communications, Vol. 12, Issue 1