Optimized anion exchange column isolation of zirconium-89 (89Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform

O’Hara, Matthew J.; Murray, Nathaniel J.; Carter, Jennifer C.; Morrison, Samuel S.

doi:10.1016/j.chroma.2018.02.053

Title: Optimized anion exchange column isolation of zirconium-89 (⁸⁹Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform

Journal Article · 24 February 2018 · Journal of Chromatography

DOI: https://doi.org/10.1016/j.chroma.2018.02.053 · OSTI ID:1422509

^[1]; Murray, Nathaniel J. ^[1]; Carter, Jennifer C. ^[1]; Morrison, Samuel S. ^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Nuclear Sciences Division

Zirconium-89 (⁸⁹Zr), produced by the (p, n) reaction from naturally monoisotopic yttrium (^natY), is a promising positron emitting isotope for immunoPET imaging. Its long half-life of 78.4 h is sufficient for evaluating slow physiological processes. A prototype automated fluidic system, coupled to on-line and in-line detectors, has been constructed to facilitate development of new ⁸⁹Zr purification methodologies. The highly reproducible reagent delivery platform and near-real time monitoring of column effluents allows for efficient method optimization. The separation of Zr from dissolved Y metal targets was evaluated using several anion exchange resins. Each resin was evaluated against its ability to quantitatively capture Zr from a load solution high in dissolved Y. The most appropriate anion exchange resin for this application was identified, and the separation method was optimized. The method is capable of a high Y decontamination factor (>10⁵) and has been shown to remove Fe, an abundant contaminant in Y foils, from the ⁸⁹Zr elution fraction. Finally, the method was evaluated using cyclotron bombarded Y foil targets; the method was shown to achieve >95% recovery of the 89Zr present in the foils. The anion exchange column method described here is intended to be the first ⁸⁹Zr isolation stage in a dual-column purification process.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP); National Institutes of Health (NIH)

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1422509

Report Number(s):: PNNL-SA-116062; PII: S0021967318302371

Journal Information:: Journal of Chromatography, Vol. 1545; ISSN 0021-9673

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Title: Optimized anion exchange column isolation of zirconium-89 (89Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform

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Title: Optimized anion exchange column isolation of zirconium-89 (⁸⁹Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform