Tandem column isolation of zirconium-89 from cyclotron bombarded yttrium targets using an automated fluidic platform: Anion exchange to hydroxamate resin columns
Abstract
The development of a tandem column purification method for the preparation of high-purity 89Zr(IV) oxalate is presented. The primary column was a macroporous strongly basic anion exchange resin on styrene divinylbenzene co-polymer. The secondary column, with an internal volume of 33 μL, was packed with hydroxamate resin. A condition of inverted selectivity was developed, whereby the 89Zr eluent solution for the primary column is equivalent to the 89Zr load solution for the secondary column. The ability to transfer 89Zr from one column to the next allows two sequential column clean-up methods to be performed prior to the final elution of the 89Zr(IV) oxalate. This approach assures delivery of high purity 89Zr product and assures a 89Zr product that is eluted in a substantially smaller volume than is possible when using the traditionally-employed single hydroxamate resin column method. The tandem column purification process has been implemented into a prototype automated fluidic system. The system is configured with on-line gamma detection so column effluents can be monitored in near-real time. The automated method was tested using seven cyclotron bombarded Y foil targets. It was found that 95.1 ± 1.3% of the 89Zr present in the foils was recovered in the secondary columnmore »
- Authors:
-
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Nuclear Sciences Division
- Oregon Health & Science Univ., Portland, OR (United States). Center for Radiochemistry Research, Department of Diagnostic Radiology
- Publication Date:
- Research Org.:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1463331
- Alternate Identifier(s):
- OSTI ID: 1702371
- Report Number(s):
- PNNL-SA-134266
Journal ID: ISSN 0021-9673; PII: S002196731830791X
- Grant/Contract Number:
- S10-RR017229; AC0576RL01830; AC06-67RLO 1830
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Chromatography
- Additional Journal Information:
- Journal Volume: 1567; Journal Issue: C; Journal ID: ISSN 0021-9673
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 36 MATERIALS SCIENCE; 89Zr; PET imaging; Medical isotope; Laboratory automation; Hydroxamate; Anion exchange; Deferoxamine
Citation Formats
O?Hara, Matthew J., Murray, Nathaniel J., Carter, Jennifer C., Kellogg, Cynthia M., and Link, Jeanne M.. Tandem column isolation of zirconium-89 from cyclotron bombarded yttrium targets using an automated fluidic platform: Anion exchange to hydroxamate resin columns. United States: N. p., 2018.
Web. doi:10.1016/J.CHROMA.2018.06.035.
O?Hara, Matthew J., Murray, Nathaniel J., Carter, Jennifer C., Kellogg, Cynthia M., & Link, Jeanne M.. Tandem column isolation of zirconium-89 from cyclotron bombarded yttrium targets using an automated fluidic platform: Anion exchange to hydroxamate resin columns. United States. https://doi.org/10.1016/J.CHROMA.2018.06.035
O?Hara, Matthew J., Murray, Nathaniel J., Carter, Jennifer C., Kellogg, Cynthia M., and Link, Jeanne M.. Tue .
"Tandem column isolation of zirconium-89 from cyclotron bombarded yttrium targets using an automated fluidic platform: Anion exchange to hydroxamate resin columns". United States. https://doi.org/10.1016/J.CHROMA.2018.06.035. https://www.osti.gov/servlets/purl/1463331.
@article{osti_1463331,
title = {Tandem column isolation of zirconium-89 from cyclotron bombarded yttrium targets using an automated fluidic platform: Anion exchange to hydroxamate resin columns},
author = {O?Hara, Matthew J. and Murray, Nathaniel J. and Carter, Jennifer C. and Kellogg, Cynthia M. and Link, Jeanne M.},
abstractNote = {The development of a tandem column purification method for the preparation of high-purity 89Zr(IV) oxalate is presented. The primary column was a macroporous strongly basic anion exchange resin on styrene divinylbenzene co-polymer. The secondary column, with an internal volume of 33 μL, was packed with hydroxamate resin. A condition of inverted selectivity was developed, whereby the 89Zr eluent solution for the primary column is equivalent to the 89Zr load solution for the secondary column. The ability to transfer 89Zr from one column to the next allows two sequential column clean-up methods to be performed prior to the final elution of the 89Zr(IV) oxalate. This approach assures delivery of high purity 89Zr product and assures a 89Zr product that is eluted in a substantially smaller volume than is possible when using the traditionally-employed single hydroxamate resin column method. The tandem column purification process has been implemented into a prototype automated fluidic system. The system is configured with on-line gamma detection so column effluents can be monitored in near-real time. The automated method was tested using seven cyclotron bombarded Y foil targets. It was found that 95.1 ± 1.3% of the 89Zr present in the foils was recovered in the secondary column elution fraction. Furthermore, elution peak analysis of several 89Zr elution profile radiochromatograms made possible the determination of 89Zr recovery as a function of volume; a 89Zr product volume that contains 90% of the mean secondary column elution peak can be obtained in 0.29 ± 0.06 mL (representing 86 ± 5% of the 89Zr activity in the target). This product volume represents a significant improvement in radionuclide product concentration over the predominant method used in the field. In addition to the reduced 89Zr product elution volume, titrations of the 89Zr product with deferoxamine mesylate salt across two preparatory methods resulted in mean effective specific activity (ESA) values of 279 and 340 T Bq·mmole-1 and mean bindable metals concentrations ([MB]) of 13.5 and 16.7 nmole·g-1. In conclusion, these ESA and [MB] values infer that the 89Zr(IV) oxalate product resulting from this tandem column isolation method has the highest purity reported to date.},
doi = {10.1016/J.CHROMA.2018.06.035},
journal = {Journal of Chromatography},
number = C,
volume = 1567,
place = {United States},
year = {2018},
month = {7}
}
Web of Science
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Works referencing / citing this record:
Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets
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