Optimized anion exchange column isolation of zirconium-89 (89Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform

O’Hara, Matthew J.; Murray, Nathaniel J.; Carter, Jennifer C.; Morrison, Samuel S.

doi:10.1016/j.chroma.2018.02.053

Title: Optimized anion exchange column isolation of zirconium-89 (⁸⁹Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform

Abstract

Zirconium-89 (⁸⁹Zr), produced by the (p, n) reaction from naturally monoisotopic yttrium (^natY), is a promising positron emitting isotope for immunoPET imaging. Its long half-life of 78.4 h is sufficient for evaluating slow physiological processes. A prototype automated fluidic system, coupled to on-line and in-line detectors, has been constructed to facilitate development of new ⁸⁹Zr purification methodologies. The highly reproducible reagent delivery platform and near-real time monitoring of column effluents allows for efficient method optimization. The separation of Zr from dissolved Y metal targets was evaluated using several anion exchange resins. Each resin was evaluated against its ability to quantitatively capture Zr from a load solution high in dissolved Y. The most appropriate anion exchange resin for this application was identified, and the separation method was optimized. The method is capable of a high Y decontamination factor (>10⁵) and has been shown to remove Fe, an abundant contaminant in Y foils, from the ⁸⁹Zr elution fraction. Finally, the method was evaluated using cyclotron bombarded Y foil targets; the method was shown to achieve >95% recovery of the 89Zr present in the foils. The anion exchange column method described here is intended to be the first ⁸⁹Zr isolation stage in amore » dual-column purification process.« less

Authors:

^[1]; Murray, Nathaniel J. ^[1]; Carter, Jennifer C. ^[1]; Morrison, Samuel S. ^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Nuclear Sciences Division

Publication Date:: Sat Feb 24 00:00:00 EST 2018

Research Org.:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Nuclear Physics (NP); National Institutes of Health (NIH)

OSTI Identifier:: 1422509

Report Number(s):: PNNL-SA-116062
Journal ID: ISSN 0021-9673; PII: S0021967318302371

Grant/Contract Number:: AC05-76RL01830

Resource Type:: Accepted Manuscript

Journal Name:: Journal of Chromatography

Additional Journal Information:: Journal Volume: 1545; Journal ID: ISSN 0021-9673

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; 60 APPLIED LIFE SCIENCES; Zirconium-89; ImmunoPET; medical isotope; automation; anion exchange; fluoride complexation

Citation Formats


                    O’Hara, Matthew J., Murray, Nathaniel J., Carter, Jennifer C., and Morrison, Samuel S. Optimized anion exchange column isolation of zirconium-89 (89Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform.  United States: N. p., 2018. 
Web.  doi:10.1016/j.chroma.2018.02.053.

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                    O’Hara, Matthew J., Murray, Nathaniel J., Carter, Jennifer C., & Morrison, Samuel S. Optimized anion exchange column isolation of zirconium-89 (89Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform.  United States.  https://doi.org/10.1016/j.chroma.2018.02.053

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                    O’Hara, Matthew J., Murray, Nathaniel J., Carter, Jennifer C., and Morrison, Samuel S. Sat .  
"Optimized anion exchange column isolation of zirconium-89 (89Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform".  United States.  https://doi.org/10.1016/j.chroma.2018.02.053.  https://www.osti.gov/servlets/purl/1422509.

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@article{osti_1422509,

  title        = {Optimized anion exchange column isolation of zirconium-89 (89Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform},

  author       = {O’Hara, Matthew J. and Murray, Nathaniel J. and Carter, Jennifer C. and Morrison, Samuel S.},

  abstractNote = {Zirconium-89 (89Zr), produced by the (p, n) reaction from naturally monoisotopic yttrium (natY), is a promising positron emitting isotope for immunoPET imaging. Its long half-life of 78.4 h is sufficient for evaluating slow physiological processes. A prototype automated fluidic system, coupled to on-line and in-line detectors, has been constructed to facilitate development of new 89Zr purification methodologies. The highly reproducible reagent delivery platform and near-real time monitoring of column effluents allows for efficient method optimization. The separation of Zr from dissolved Y metal targets was evaluated using several anion exchange resins. Each resin was evaluated against its ability to quantitatively capture Zr from a load solution high in dissolved Y. The most appropriate anion exchange resin for this application was identified, and the separation method was optimized. The method is capable of a high Y decontamination factor (>105) and has been shown to remove Fe, an abundant contaminant in Y foils, from the 89Zr elution fraction. Finally, the method was evaluated using cyclotron bombarded Y foil targets; the method was shown to achieve >95% recovery of the 89Zr present in the foils. The anion exchange column method described here is intended to be the first 89Zr isolation stage in a dual-column purification process.},

  doi          = {10.1016/j.chroma.2018.02.053},

  journal      = {Journal of Chromatography},

  number       = ,

  volume       = 1545,

  place        = {United States},

  year         = {Sat Feb 24 00:00:00 EST 2018},

  month        = {Sat Feb 24 00:00:00 EST 2018}

}

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Zirconium-89 (89Zr), produced by the (p,n) reaction from naturally monoisotopic yttrium (natY), is a promising positron emitting isotope for immunoPET imaging. Its long half-life of 78.4 h is sufficient for evaluating slow physiological processes. A prototype automated fluidic system, coupled to on-line and in-line detectors, has been constructed to facilitate development of new 89Zr purification methodologies. The highly reproducible reagent delivery platform and near-real time monitoring of column effluents allows for efficient method optimization. The separation of Zr from dissolved Y metal targets was evaluated using several anion exchange resins. Each resin was evaluated against its ability to quantitatively capturemore »« less
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Title: Optimized anion exchange column isolation of zirconium-89 (89Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform

Abstract

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A comparative study on the separation of radiozirconium via ion-exchange and solvent extraction techniques, with particular reference to the production of 88Zr and 89Zr in proton induced reactions on yttrium journal, October 2007

Proton induced reactions on 89Y with particular reference to the production of the medically interesting radionuclide 89Zr journal, January 2009

Production of highly pure no-carrier added 89Zr for the labelling of antibodies with a positron emitter journal, December 1994

Production of Zr-89 using sputtered yttrium coin targets journal, July 2017

Routine Production of 89Zr Using an Automated Module journal, July 2013

Measurements and a direct-reaction – plus – Hauser-Feshbach analysis of Y 89 ( p , n ) 89 Zr, Y 89 ( p ,2 n ) 88 , and Y 89 ( p , pn ) 88 Y reactions up to 40 MeV journal, October 1988

Quantum mechanical investigation of aqueous desferrioxamine B metal complexes: Trends in structure, binding, and infrared spectroscopy journal, December 2013

Stability constants for complexes of the siderophore desferrioxamine B with selected heavy metal cations journal, March 1996

Ti(IV) and the Siderophore Desferrioxamine B: A Tight Complex Has Biological and Environmental Implications journal, January 2017

Distribution coefficients and ion exchange behavior of 46 elements with a macroreticular cation exchange resin in hydrochloric acid journal, May 1984

Ion exchange procedures journal, January 1964

Zirconium and Hafnium Separation, Part 2. Solid/Liquid Extraction in Hydrochloric Acid Aqueous Solution with Anion Exchange Resins journal, September 2006

A simple and convenient method for production of 89Zr with high purity journal, December 2016

Cyclotron production and radiochemical purification of 88,89Zr via α-particle induced reactions on natural strontium journal, August 2014

Production of no-carrier-added zirconium-89 for positron emission tomography journal, January 1991

Semi-automated production of 89 Zr-oxalate/ 89 Zr-chloride and the potential of 89 Zr-chloride in radiopharmaceutical compounding journal, January 2016

ADSORPTION OF IRON BY ANION EXCHANGE RESINS FROM HYDROCHLORIC ACID SOLUTIONS 1 journal, December 1950

Zirconium and Hafnium Separation, Part 1. Liquid/Liquid Extraction in Hydrochloric Acid Aqueous Solution with Aliquat 336 journal, July 2006

Extraction of zirconium(IV) from HCl solutions by mixtures of Aliquat-336 and Alamine-336 with TBP journal, December 1989

Ion exchange in aqueous and in aqueous-organic solvents journal, March 1973

Behaviour of Zr, Hf, Nb, Ta and Pa on macroporous anion exchanger in chloride–fluoride media journal, November 1998

Anion Exchange Studies. I. Separation of Zirconium and Niobium in HCl-HF Mixtures 1 journal, January 1951

Oxidation of hydrogen chloride with hydrogen peroxide in aqueous solution journal, January 2008

Radiometals for imaging and theranostics, current production, and future perspectives journal, July 2019

Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets journal, December 2019

Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets journal, December 2019

Title: Optimized anion exchange column isolation of zirconium-89 (⁸⁹Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform

Radioimmunoimaging with Longer-Lived Positron-Emitting Radionuclides: Potentials and Challenges
journal, May 2009

Immuno-Positron Emission Tomography with Zirconium-89-Labeled Monoclonal Antibodies in Oncology: What Can We Learn from Initial Clinical Trials?
journal, May 2016

89Zr-trastuzumab and 89Zr-bevacizumab PET to Evaluate the Effect of the HSP90 Inhibitor NVP-AUY922 in Metastatic Breast Cancer Patients
journal, July 2014

89Zr-cetuximab PET imaging in patients with advanced colorectal cancer
journal, July 2015

Tumour targeting and radiation dose of radioimmunotherapy with 90Y-rituximab in CD20+ B-cell lymphoma as predicted by 89Zr-rituximab immuno-PET: impact of preloading with unlabelled rituximab
journal, March 2015

Noninvasive Imaging of PSMA in Prostate Tumors with ⁸⁹ Zr-Labeled huJ591 Engineered Antibody Fragments: The Faster Alternatives
journal, April 2014

Glypican-3-Targeting F(ab')2 for 89Zr PET of Hepatocellular Carcinoma
journal, October 2014

Immuno-PET: A Navigator in Monoclonal Antibody Development and Applications
journal, December 2007

Pairwise comparison of 89Zr- and 124I-labeled cG250 based on positron emission tomography imaging and nonlinear immunokinetic modeling: in vivo carbonic anhydrase IX receptor binding and internalization in mouse xenografts of clear-cell renal cell carcinoma
journal, March 2014

Zirconium-89 Labeled Antibodies: A New Tool for Molecular Imaging in Cancer Patients
journal, January 2014

PET Tracers Based on Zirconium-89
journal, April 2011

Unconventional Nuclides for Radiopharmaceuticals
journal, January 2010

The Next Generation of Positron Emission Tomography Radiopharmaceuticals in Oncology
journal, July 2011

The rise of metal radionuclides in medical imaging: copper-64, zirconium-89 and yttrium-86
journal, April 2011

Review on Production of 89Zr in a Medical Cyclotron for PET Radiopharmaceuticals
journal, January 2013

89Zr Radiochemistry for Positron Emission Tomography
journal, September 2011

PET imaging with 89Zr: From radiochemistry to the clinic
journal, January 2013

⁸⁹ Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art ⁸⁹ Zr Radiochemistry
journal, August 2017

Standardisation and half-life of 89 Zr
journal, April 2018

Production of 88,89Zr by proton induced activation of natY and separation by SLX and LLX
journal, June 2009

Standardized methods for the production of high specific-activity zirconium-89
journal, October 2009

Some experimental studies on ⁸⁹ Zr production
journal, January 2011

Implementation of 89Zr production and in vivo imaging of B-cells in mice with 89Zr-labeled anti-B-cell antibodies by small animal PET/CT
journal, June 2011

A simple thick target for production of 89Zr using an 11 MeV cyclotron
journal, April 2017

A comparative study on the separation of radiozirconium via ion-exchange and solvent extraction techniques, with particular reference to the production of 88Zr and 89Zr in proton induced reactions on yttrium
journal, October 2007

Proton induced reactions on 89Y with particular reference to the production of the medically interesting radionuclide 89Zr
journal, January 2009

Production of highly pure no-carrier added 89Zr for the labelling of antibodies with a positron emitter
journal, December 1994

Production of Zr-89 using sputtered yttrium coin targets
journal, July 2017

Routine Production of 89Zr Using an Automated Module
journal, July 2013

Measurements and a direct-reaction – plus – Hauser-Feshbach analysis of ${}^{89}Y$ ( p , n $)^{89}$ Zr, ${}^{89}Y$ ( p ,2 n $)^{88}$ , and ${}^{89}Y$ ( p , pn $)^{88}$ Y reactions up to 40 MeV
journal, October 1988

Quantum mechanical investigation of aqueous desferrioxamine B metal complexes: Trends in structure, binding, and infrared spectroscopy
journal, December 2013

Stability constants for complexes of the siderophore desferrioxamine B with selected heavy metal cations
journal, March 1996

Ti(IV) and the Siderophore Desferrioxamine B: A Tight Complex Has Biological and Environmental Implications
journal, January 2017

Distribution coefficients and ion exchange behavior of 46 elements with a macroreticular cation exchange resin in hydrochloric acid
journal, May 1984

Ion exchange procedures
journal, January 1964

Zirconium and Hafnium Separation, Part 2. Solid/Liquid Extraction in Hydrochloric Acid Aqueous Solution with Anion Exchange Resins
journal, September 2006

A simple and convenient method for production of 89Zr with high purity
journal, December 2016

Cyclotron production and radiochemical purification of 88,89Zr via α-particle induced reactions on natural strontium
journal, August 2014

Production of no-carrier-added zirconium-89 for positron emission tomography
journal, January 1991

Semi-automated production of 89 Zr-oxalate/ 89 Zr-chloride and the potential of 89 Zr-chloride in radiopharmaceutical compounding
journal, January 2016

ADSORPTION OF IRON BY ANION EXCHANGE RESINS FROM HYDROCHLORIC ACID SOLUTIONS ¹
journal, December 1950

Zirconium and Hafnium Separation, Part 1. Liquid/Liquid Extraction in Hydrochloric Acid Aqueous Solution with Aliquat 336
journal, July 2006

Extraction of zirconium(IV) from HCl solutions by mixtures of Aliquat-336 and Alamine-336 with TBP
journal, December 1989

Ion exchange in aqueous and in aqueous-organic solvents
journal, March 1973

Behaviour of Zr, Hf, Nb, Ta and Pa on macroporous anion exchanger in chloride–fluoride media
journal, November 1998

Anion Exchange Studies. I. Separation of Zirconium and Niobium in HCl-HF Mixtures ¹
journal, January 1951

Oxidation of hydrogen chloride with hydrogen peroxide in aqueous solution
journal, January 2008

Radiometals for imaging and theranostics, current production, and future perspectives
journal, July 2019

Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets
journal, December 2019

Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets
journal, December 2019