DOE Patents DOE Patents
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information
Search DOE Patents

Title: Rigid bifunctional chelating agents

Abstract

Bicyclo›2.2.2! octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo›2.2.1! heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

Inventors:
 [1];  [2];  [3]
+ Show Inventor Affiliations
  1. Coram, NY
  2. Fairfax, VA
  3. Setauket, NY
Issue Date:
Research Org.:
Associated Universities, Inc., Upton, NY (United States)
OSTI Identifier:
871721
Patent Number(s):
5783169
Application Number:
08/506,889
Assignee:
Brookhaven Science Associates LLC (Upton, NY)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Show more
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
rigid; bifunctional; chelating; agents; bicyclo2; octane-2; diamine-n; -tetraacetic; acids; bodta; heptane-2; acid; bhdta; useful; forming; detectably; labeled; bioconjugate; compounds; diagnostic; therapeutic; purposes; processes; disclosed; radioimmunoconjugates; prolonged; tumor; uptake; normal; tissue; uptakes; therapeutic purposes; -tetraacetic acid; bifunctional chelating; acetic acid; chelating agents; chelating agent; tumor uptake; agents useful; rigid bifunctional; normal tissue; -tetraacetic acids; forming detectably; detectably labeled; labeled bioconjugate; /424/999/

Citation Formats

Sweet, Mark P, Mease, Ronnie C, and Srivastava, Suresh C. Rigid bifunctional chelating agents. United States: N. p., 1998. Web.
Copy to clipboard
Sweet, Mark P, Mease, Ronnie C, & Srivastava, Suresh C. Rigid bifunctional chelating agents. United States.
Copy to clipboard
Sweet, Mark P, Mease, Ronnie C, and Srivastava, Suresh C. Tue . "Rigid bifunctional chelating agents". United States. https://www.osti.gov/servlets/purl/871721.
Copy to clipboard
@article{osti_871721,
title = {Rigid bifunctional chelating agents},
author = {Sweet, Mark P and Mease, Ronnie C and Srivastava, Suresh C},
abstractNote = {Bicyclo›2.2.2! octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo›2.2.1! heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 21 00:00:00 EDT 1998},
month = {Tue Jul 21 00:00:00 EDT 1998}
}
Copy to clipboard
Patent:
View Patent
Save / Share:
Export Metadata
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.

Works referenced in this record:

A retro-Diels-Alder approach to oxazoles and imidazoles
journal, June 1993

    [ × clear filter / sort ]

    Similar Records in DOE Patents and OSTI.GOV collections: