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Title: Macrocyclic bifunctional chelating agents

Abstract

A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.

Inventors:
 [1];  [2];  [3];  [1]
  1. Davis, CA
  2. El Macero, CA
  3. Houston, TX
Issue Date:
Research Org.:
NATIONAL BUREAU OF STANDARDS
OSTI Identifier:
866304
Patent Number(s):
4678667
Assignee:
University of California (Berkeley, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AT03-82ER60056
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
macrocyclic; bifunctional; chelating; agents; copper; chelate; conjugate; stable; human; serum; cyclic; tetraaza; di-; tri-; tetra-acetic; acid; linker; attached; carbon; biomolecule; joined; linker-copper; compound; forming; designed; diagnostic; therapeutic; applications; involve; cu; ii; localization; via; systemic; route; bifunctional chelating; acetic acid; chelating agents; chelating agent; human serum; copper chelate; /424/999/

Citation Formats

Meares, Claude F, DeNardo, Sally J, Cole, William C, and Mol, Min K. Macrocyclic bifunctional chelating agents. United States: N. p., 1987. Web.
Meares, Claude F, DeNardo, Sally J, Cole, William C, & Mol, Min K. Macrocyclic bifunctional chelating agents. United States.
Meares, Claude F, DeNardo, Sally J, Cole, William C, and Mol, Min K. Thu . "Macrocyclic bifunctional chelating agents". United States. https://www.osti.gov/servlets/purl/866304.
@article{osti_866304,
title = {Macrocyclic bifunctional chelating agents},
author = {Meares, Claude F and DeNardo, Sally J and Cole, William C and Mol, Min K},
abstractNote = {A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1987},
month = {1}
}

Patent:

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