Macrocyclic bifunctional chelating agents
Abstract
A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.
- Inventors:
-
- Davis, CA
- El Macero, CA
- Houston, TX
- Issue Date:
- Research Org.:
- NATIONAL BUREAU OF STANDARDS
- OSTI Identifier:
- 866304
- Patent Number(s):
- 4678667
- Assignee:
- University of California (Berkeley, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- AT03-82ER60056
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- macrocyclic; bifunctional; chelating; agents; copper; chelate; conjugate; stable; human; serum; cyclic; tetraaza; di-; tri-; tetra-acetic; acid; linker; attached; carbon; biomolecule; joined; linker-copper; compound; forming; designed; diagnostic; therapeutic; applications; involve; cu; ii; localization; via; systemic; route; bifunctional chelating; acetic acid; chelating agents; chelating agent; human serum; copper chelate; /424/999/
Citation Formats
Meares, Claude F, DeNardo, Sally J, Cole, William C, and Mol, Min K. Macrocyclic bifunctional chelating agents. United States: N. p., 1987.
Web.
Meares, Claude F, DeNardo, Sally J, Cole, William C, & Mol, Min K. Macrocyclic bifunctional chelating agents. United States.
Meares, Claude F, DeNardo, Sally J, Cole, William C, and Mol, Min K. Thu .
"Macrocyclic bifunctional chelating agents". United States. https://www.osti.gov/servlets/purl/866304.
@article{osti_866304,
title = {Macrocyclic bifunctional chelating agents},
author = {Meares, Claude F and DeNardo, Sally J and Cole, William C and Mol, Min K},
abstractNote = {A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1987},
month = {1}
}