Macrocyclic bifunctional chelating agents

Meares, Claude F; DeNardo, Sally J; Cole, William C; Mol, Min K

Title: Macrocyclic bifunctional chelating agents

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Abstract

A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.

Inventors:

Meares, Claude F ^[1]; DeNardo, Sally J ^[2]; Cole, William C ^[3]; Mol, Min K ^[1]

Davis, CA
El Macero, CA
Houston, TX

Issue Date:: 1987-01-01

Research Org.:: NATIONAL BUREAU OF STANDARDS

OSTI Identifier:: 866304

Patent Number(s):: 4678667

Assignee:: University of California (Berkeley, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2123/00 - Preparations for testing in vivo
A61K51/1093 - {conjugates with carriers being antibodies}
A61K47/6887 - {Antibody-chelate conjugates using chelates for therapeutic purposes
A61K51/0482 - {chelates from cyclic ligands, e.g. DOTA}
A61K49/106 - {the complex-forming compound being cyclic, e.g. DOTA}
A61K2121/00 - Preparations for use in therapy
A61K49/16 - Antibodies
A61K49/085 - {conjugated systems}

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DOE Contract Number:: AT03-82ER60056

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: macrocyclic; bifunctional; chelating; agents; copper; chelate; conjugate; stable; human; serum; cyclic; tetraaza; di-; tri-; tetra-acetic; acid; linker; attached; carbon; biomolecule; joined; linker-copper; compound; forming; designed; diagnostic; therapeutic; applications; involve; cu; ii; localization; via; systemic; route; bifunctional chelating; acetic acid; chelating agents; chelating agent; human serum; copper chelate; /424/999/

Citation Formats


                    Meares, Claude F, DeNardo, Sally J, Cole, William C, and Mol, Min K. Macrocyclic bifunctional chelating agents.  United States: N. p., 1987. 
        Web.

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                    Meares, Claude F, DeNardo, Sally J, Cole, William C, & Mol, Min K. Macrocyclic bifunctional chelating agents.  United States.

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                    Meares, Claude F, DeNardo, Sally J, Cole, William C, and Mol, Min K. Thu .  
        "Macrocyclic bifunctional chelating agents".  United States.  https://www.osti.gov/servlets/purl/866304.

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@article{osti_866304,

  title        = {Macrocyclic bifunctional chelating agents},

  author       = {Meares, Claude F and DeNardo, Sally J and Cole, William C and Mol, Min K},

  abstractNote = {A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1987},

  month        = {1}

}

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