Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy
Abstract
There is provided a method of labeling a biomolecule with a transition metal or radiometal in a site specific manner to produce a diagnostic or therapeutic pharmaceutical compound by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radio metal or a transition metal, and covalently linking the resulting metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. Also provided is a method of synthesizing the --PR.sub.2 containing biomolecules by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radiometal or a transition metal, and covalently linking the resulting radio metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. There is provided a therapeutic or diagnostic agent comprising a --PR.sub.2 containing biomolecule.
- Inventors:
- Issue Date:
- Research Org.:
- The Curators of the University of Missouri, Columbia, MO, (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1174538
- Patent Number(s):
- 6635235
- Application Number:
- 09/602,487
- Assignee:
- The Curators of the University of Missouri (Columbia, MO)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- FG02-89ER60875
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Katti, Kattesh V., Prabhu, Kandikere R., Gali, Hariprasad, Pillarsetty, Nagavara Kishore, and Volkert, Wynn A. Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy. United States: N. p., 2003.
Web.
Katti, Kattesh V., Prabhu, Kandikere R., Gali, Hariprasad, Pillarsetty, Nagavara Kishore, & Volkert, Wynn A. Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy. United States.
Katti, Kattesh V., Prabhu, Kandikere R., Gali, Hariprasad, Pillarsetty, Nagavara Kishore, and Volkert, Wynn A. Tue .
"Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy". United States. https://www.osti.gov/servlets/purl/1174538.
@article{osti_1174538,
title = {Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy},
author = {Katti, Kattesh V. and Prabhu, Kandikere R. and Gali, Hariprasad and Pillarsetty, Nagavara Kishore and Volkert, Wynn A.},
abstractNote = {There is provided a method of labeling a biomolecule with a transition metal or radiometal in a site specific manner to produce a diagnostic or therapeutic pharmaceutical compound by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radio metal or a transition metal, and covalently linking the resulting metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. Also provided is a method of synthesizing the --PR.sub.2 containing biomolecules by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radiometal or a transition metal, and covalently linking the resulting radio metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. There is provided a therapeutic or diagnostic agent comprising a --PR.sub.2 containing biomolecule.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {10}
}
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