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Title: Rigid bifunctional chelating agents

Abstract

Bicyclo[2.2.2]octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo[2.2.1]heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

Inventors:
 [1];  [2];  [3]
  1. (Coram, NY)
  2. (Fairfax, VA)
  3. (Setauket, NY)
Issue Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
872845
Patent Number(s):
6022522
Application Number:
09/046,030
Assignee:
Brookhaven Science Associates (Upton, NY) BNL
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
rigid; bifunctional; chelating; agents; bicyclo; octane-2; diamine-n; -tetraacetic; acids; bodta; heptane-2; acid; bhdta; useful; forming; detectably; labeled; bioconjugate; compounds; diagnostic; therapeutic; purposes; processes; disclosed; radioimmunoconjugates; prolonged; tumor; uptake; normal; tissue; uptakes; therapeutic purposes; -tetraacetic acid; bifunctional chelating; acetic acid; chelating agents; chelating agent; tumor uptake; agents useful; rigid bifunctional; normal tissue; -tetraacetic acids; forming detectably; detectably labeled; labeled bioconjugate; /424/999/

Citation Formats

Sweet, Mark P., Mease, Ronnie C., and Srivastava, Suresh C. Rigid bifunctional chelating agents. United States: N. p., 2000. Web.
Sweet, Mark P., Mease, Ronnie C., & Srivastava, Suresh C. Rigid bifunctional chelating agents. United States.
Sweet, Mark P., Mease, Ronnie C., and Srivastava, Suresh C. Tue . "Rigid bifunctional chelating agents". United States. https://www.osti.gov/servlets/purl/872845.
@article{osti_872845,
title = {Rigid bifunctional chelating agents},
author = {Sweet, Mark P. and Mease, Ronnie C. and Srivastava, Suresh C.},
abstractNote = {Bicyclo[2.2.2]octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo[2.2.1]heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {2}
}

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