Polarization transfer NMR imaging
Abstract
A nuclear magnetic resonance (NMR) image is obtained with spatial information modulated by chemical information. The modulation is obtained through polarization transfer from a first element representing the desired chemical, or functional, information, which is covalently bonded and spin-spin coupled with a second element effective to provide the imaging data. First and second rf pulses are provided at first and second frequencies for exciting the imaging and functional elements, with imaging gradients applied therebetween to spatially separate the nuclei response for imaging. The second rf pulse is applied at a time after the first pulse which is the inverse of the spin coupling constant to select the transfer element nuclei which are spin coupled to the functional element nuclei for imaging. In a particular application, compounds such as glucose, lactate, or lactose, can be labeled with .sup.13 C and metabolic processes involving the compounds can be imaged with the sensitivity of .sup.1 H and the selectivity of .sup.13 C.
- Inventors:
-
- Los Alamos, NM
- Santa Fe, NM
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- OSTI Identifier:
- 867365
- Patent Number(s):
- 4922203
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- polarization; transfer; nmr; imaging; nuclear; magnetic; resonance; image; obtained; spatial; information; modulated; chemical; modulation; element; representing; desired; functional; covalently; bonded; spin-spin; coupled; effective; provide; data; rf; pulses; provided; frequencies; exciting; elements; gradients; applied; therebetween; spatially; separate; nuclei; response; pulse; time; inverse; spin; coupling; constant; select; particular; application; compounds; glucose; lactate; lactose; labeled; 13; metabolic; processes; involving; imaged; sensitivity; selectivity; nmr imaging; particular application; magnetic resonance; nuclear magnetic; covalently bonded; rf pulses; spatial information; processes involving; chemical information; rf pulse; functional elements; desired chemical; spatially separate; polarization transfer; /324/
Citation Formats
Sillerud, Laurel O, and van Hulsteyn, David B. Polarization transfer NMR imaging. United States: N. p., 1990.
Web.
Sillerud, Laurel O, & van Hulsteyn, David B. Polarization transfer NMR imaging. United States.
Sillerud, Laurel O, and van Hulsteyn, David B. Mon .
"Polarization transfer NMR imaging". United States. https://www.osti.gov/servlets/purl/867365.
@article{osti_867365,
title = {Polarization transfer NMR imaging},
author = {Sillerud, Laurel O and van Hulsteyn, David B},
abstractNote = {A nuclear magnetic resonance (NMR) image is obtained with spatial information modulated by chemical information. The modulation is obtained through polarization transfer from a first element representing the desired chemical, or functional, information, which is covalently bonded and spin-spin coupled with a second element effective to provide the imaging data. First and second rf pulses are provided at first and second frequencies for exciting the imaging and functional elements, with imaging gradients applied therebetween to spatially separate the nuclei response for imaging. The second rf pulse is applied at a time after the first pulse which is the inverse of the spin coupling constant to select the transfer element nuclei which are spin coupled to the functional element nuclei for imaging. In a particular application, compounds such as glucose, lactate, or lactose, can be labeled with .sup.13 C and metabolic processes involving the compounds can be imaged with the sensitivity of .sup.1 H and the selectivity of .sup.13 C.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1990},
month = {Mon Jan 01 00:00:00 EST 1990}
}