Site-specific dynamic nuclear polarization NMR agents
Dynamic nuclear polarization (DNP) agents are provided for DNP nuclear magnetic resonance of analytes. The DNP agents can have the structure A-X-L-R, where A is none or an amphiphilic group; X is a coupling group capable of site-specific binding with the analyte or, when A is an amphiphilic group, capable of site-specific binding with the amphiphilic group; L is a bond or a linker group; and R is a poly-radical group. The poly-radical can be a di-radical, a tri-radical, a tetra-radical, or a combination thereof. Methods of NMR measurement of an analyte comprising an NMR-detectable nucleus are provided. The methods can include the steps of providing a frozen sample containing the analyte and a DNP agent; applying radiation having a frequency that excites electron spin transitions in the DNP agent at an intensity to polarize the NMR-detectable nucleus; and detecting a signal from nuclear spin transitions in the NMR-detectable nucleus.
- Research Organization:
- North Carolina State University, Raleigh, NC (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-02ER15354
- Assignee:
- North Carolina State University (Raleigh, NC)
- Patent Number(s):
- 10,414,729
- Application Number:
- 15/222,428
- OSTI ID:
- 1576300
- Resource Relation:
- Patent File Date: 2016 Jul 28
- Country of Publication:
- United States
- Language:
- English
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