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Title: Site-specific dynamic nuclear polarization NMR agents

Abstract

Dynamic nuclear polarization (DNP) agents are provided for DNP nuclear magnetic resonance of analytes. The DNP agents can have the structure A-X-L-R, where A is none or an amphiphilic group; X is a coupling group capable of site-specific binding with the analyte or, when A is an amphiphilic group, capable of site-specific binding with the amphiphilic group; L is a bond or a linker group; and R is a poly-radical group. The poly-radical can be a di-radical, a tri-radical, a tetra-radical, or a combination thereof. Methods of NMR measurement of an analyte comprising an NMR-detectable nucleus are provided. The methods can include the steps of providing a frozen sample containing the analyte and a DNP agent; applying radiation having a frequency that excites electron spin transitions in the DNP agent at an intensity to polarize the NMR-detectable nucleus; and detecting a signal from nuclear spin transitions in the NMR-detectable nucleus.

Inventors:
;
Issue Date:
Research Org.:
North Carolina State Univ., Raleigh, NC (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1576300
Patent Number(s):
10,414,729
Application Number:
15/222,428
Assignee:
North Carolina State University (Raleigh, NC)
DOE Contract Number:  
FG02-02ER15354
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 Jul 28
Country of Publication:
United States
Language:
English

Citation Formats

Smirnov, Alexej I., and Voynov, Maxim Anatolyevich. Site-specific dynamic nuclear polarization NMR agents. United States: N. p., 2019. Web.
Smirnov, Alexej I., & Voynov, Maxim Anatolyevich. Site-specific dynamic nuclear polarization NMR agents. United States.
Smirnov, Alexej I., and Voynov, Maxim Anatolyevich. Tue . "Site-specific dynamic nuclear polarization NMR agents". United States. https://www.osti.gov/servlets/purl/1576300.
@article{osti_1576300,
title = {Site-specific dynamic nuclear polarization NMR agents},
author = {Smirnov, Alexej I. and Voynov, Maxim Anatolyevich},
abstractNote = {Dynamic nuclear polarization (DNP) agents are provided for DNP nuclear magnetic resonance of analytes. The DNP agents can have the structure A-X-L-R, where A is none or an amphiphilic group; X is a coupling group capable of site-specific binding with the analyte or, when A is an amphiphilic group, capable of site-specific binding with the amphiphilic group; L is a bond or a linker group; and R is a poly-radical group. The poly-radical can be a di-radical, a tri-radical, a tetra-radical, or a combination thereof. Methods of NMR measurement of an analyte comprising an NMR-detectable nucleus are provided. The methods can include the steps of providing a frozen sample containing the analyte and a DNP agent; applying radiation having a frequency that excites electron spin transitions in the DNP agent at an intensity to polarize the NMR-detectable nucleus; and detecting a signal from nuclear spin transitions in the NMR-detectable nucleus.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {9}
}

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