Remote NMR/MRI detection of laser polarized gases

Pines, Alexander; Saxena, Sunil; Moule, Adam; Spence, Megan; Seeley, Juliette A.; Pierce, Kimberly L.; Han, Song-I; Granwehr, Josef

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Title: Remote NMR/MRI detection of laser polarized gases

Abstract

An apparatus and method for remote NMR/MRI spectroscopy having an encoding coil with a sample chamber, a supply of signal carriers, preferably hyperpolarized xenon and a detector allowing the spatial and temporal separation of signal preparation and signal detection steps. This separation allows the physical conditions and methods of the encoding and detection steps to be optimized independently. The encoding of the carrier molecules may take place in a high or a low magnetic field and conventional NMR pulse sequences can be split between encoding and detection steps. In one embodiment, the detector is a high magnetic field NMR apparatus. In another embodiment, the detector is a superconducting quantum interference device. A further embodiment uses optical detection of Rb--Xe spin exchange. Another embodiment uses an optical magnetometer using non-linear Faraday rotation. Concentration of the signal carriers in the detector can greatly improve the signal to noise ratio.

Inventors:: Pines, Alexander; Saxena, Sunil; Moule, Adam; Spence, Megan; Seeley, Juliette A.; Pierce, Kimberly L.; Han, Song-I; Granwehr, Josef

Issue Date:: Tue Jun 13 00:00:00 EDT 2006

Research Org.:: Univ. of California, Oakland, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175791

Patent Number(s):: 7061237

Application Number:: 10/268,922

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K49/1815 - {compo-inhalant, e.g. breath tests}

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/282 - {Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent}
G01R33/46 - NMR spectroscopy
G01R33/5601 - {involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent}

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DOE Contract Number:: AC0376F00098

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Pines, Alexander, Saxena, Sunil, Moule, Adam, Spence, Megan, Seeley, Juliette A., Pierce, Kimberly L., Han, Song-I, and Granwehr, Josef. Remote NMR/MRI detection of laser polarized gases.  United States: N. p., 2006. 
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                    Pines, Alexander, Saxena, Sunil, Moule, Adam, Spence, Megan, Seeley, Juliette A., Pierce, Kimberly L., Han, Song-I, & Granwehr, Josef. Remote NMR/MRI detection of laser polarized gases.  United States.

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                    Pines, Alexander, Saxena, Sunil, Moule, Adam, Spence, Megan, Seeley, Juliette A., Pierce, Kimberly L., Han, Song-I, and Granwehr, Josef. Tue .  
        "Remote NMR/MRI detection of laser polarized gases".  United States.  https://www.osti.gov/servlets/purl/1175791.

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@article{osti_1175791,

  title        = {Remote NMR/MRI detection of laser polarized gases},

  author       = {Pines, Alexander and Saxena, Sunil and Moule, Adam and Spence, Megan and Seeley, Juliette A. and Pierce, Kimberly L. and Han, Song-I and Granwehr, Josef},

  abstractNote = {An apparatus and method for remote NMR/MRI spectroscopy having an encoding coil with a sample chamber, a supply of signal carriers, preferably hyperpolarized xenon and a detector allowing the spatial and temporal separation of signal preparation and signal detection steps. This separation allows the physical conditions and methods of the encoding and detection steps to be optimized independently. The encoding of the carrier molecules may take place in a high or a low magnetic field and conventional NMR pulse sequences can be split between encoding and detection steps. In one embodiment, the detector is a high magnetic field NMR apparatus. In another embodiment, the detector is a superconducting quantum interference device. A further embodiment uses optical detection of Rb--Xe spin exchange. Another embodiment uses an optical magnetometer using non-linear Faraday rotation. Concentration of the signal carriers in the detector can greatly improve the signal to noise ratio.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jun 13 00:00:00 EDT 2006},

  month        = {Tue Jun 13 00:00:00 EDT 2006}

}

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Journal of Magnetic Resonance (1969), Vol. 97, Issue 3
https://doi.org/10.1016/0022-2364(92)90028-6

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Title: Remote NMR/MRI detection of laser polarized gases

Abstract

Citation Formats

Two new abnormal pathways in the para-Claisen rearrangement of 2(allyloxy)- and 2-(crotyloxy)-3-hydroxybenzaldehyde journal, March 1991

Enhancement of Solution NMR and MRI with Laser-Polarized Xenon journal, March 1996

Optical Pumping journal, August 1963

Discovering High-Affinity Ligands for Proteins: SAR by NMR journal, November 1996

The NMR-mouse: construction, excitation, and applications journal, June 1998

Spin-polarized xenon-129 NMR study of a polymer surface journal, February 1993

Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin journal, August 1997

129 Xe NMR Spectroscopy of Deuterium-Labeled Cryptophane-A Xenon Complexes: Investigation of Host−Guest Complexation Dynamics journal, February 2000

Polarization of Nuclei in Metals journal, October 1953

Low field magnetic resonance images of polarized noble gases obtained with a dc superconducting quantum interference device journal, April 1998

Spin-lattice relaxation of laser-polarized xenon in human blood journal, March 1999

Nuclear Magnetic Resonance Spectroscopy in the Earth Sciences: Structure and Dynamics journal, July 1989

Isolation and characterization of a thermostable aminopeptidase(aminopeptidase T) from Thermus aquaticus YT-1, an extremely thermophilic bacterium. journal, January 1988

In SituNMR Analysis of Fluids Contained in Sedimentary Rock journal, August 1998

Approach to High-Resolution ex Situ NMR Spectroscopy journal, July 2001

Voltage-sensitive magnetic gels as magnetic resonance monitoring agents journal, May 1993

NMR of laser-polarized xenon in human blood journal, November 1996

Evidence of nonspecific surface interactions between laser-polarized xenon and myoglobin in solution journal, August 2000

Fluorescence polarization — a new tool for cell and molecular biology journal, May 1995

Selective Enhancement of NMR Signals forα-Cyclodextrin with Laser-Polarized Xenon journal, November 1997

Temperature-dependent molecular motions of cholesterol esters: a carbon-13 nuclear magnetic resonance study journal, December 1982

Nuclear magnetic resonance studies of xenon-129 with myoglobin and hemoglobin journal, December 1982

Binding of Xenon to Sperm Whale Myoglobin journal, July 1965

Hyperpolarized129Xe NMR as a probe for blood oxygenation journal, April 2000

Exploring Surfaces and Cavities in Lipoxygenase and Other Proteins by Hyperpolarized Xenon-129 NMR journal, September 1999

High-field NMR of adsorbed xenon polarized by laser pumping journal, February 1991

Xenon NMR: chemical shifts of a general anesthetic in common solvents, proteins, and membranes. journal, August 1981

Introduction book, January 1971

Spin Dynamics of Carr–Purcell–Meiboom–Gill-like Sequences in Grossly Inhomogeneous B0 and B1 Fields and Application to NMR Well Logging journal, March 2000

In vivo magnetic resonance vascular imaging using laser-polarized 3He microbubbles journal, September 1998

Study of Xenon Binding in Cryptophane-A Using Laser-Induced NMR Polarization Enhancement journal, April 1999

Biospecific interaction analysis using biosensor technology journal, January 1993

Nuclear magnetic relaxation of Xenon-129 dissolved in organic solvents journal, December 1991

Measurement of high-resolution NMR spectra in an inhomogeneous magnetic field journal, November 1987

Magnetization transfer from laser-polarized xenon to protons located in the hydrophobic cavity of the wheat nonspecific lipid transfer protein journal, April 2001

High-resolution NMR spectra in inhomogeneous magnetic fields: application of total spin coherence transfer echoes journal, June 1981

High-field cross polarization NMR from laser-polarized xenon to a polymer surface journal, September 1993

Spin-exchange optical pumping of noble-gas nuclei journal, April 1997

Relaxation Processes in a System of Two Spins journal, July 1955

Spin-Polarized 129Xe Gas Imaging of Materials journal, July 1995

Some Developments in Nuclear Magnetic Resonance of Solids journal, October 1989

Maltose Transport in Escherichia coli K12. A Comparison of Transport Kinetics in Wild-Type and lamba-Resistant Mutants with the Dissociation Constants of the Maltose-Binding Protein as Measured by Fluorescence Quenching journal, May 1976

MR Imaging with Hyperpolarized3He Gas journal, February 1995

Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms journal, June 1984

Production of Thermostable Alkaline Proteases by Thermophilic Streptomyces journal, January 1969

In vivo visualization of gene expression using magnetic resonance imaging journal, March 2000

NMR of optically pumped xenon thin films journal, April 1992

Nuclear Magnetic Resonance Spectra from a Crystal rotated at High Speed journal, December 1958

Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis journal, November 1992

Diffusion Measurements with the Aid of Nutation Spin Echoes Appearing after Two Inhomogeneous Radiofrequency Pulses in Inhomogeneous Magnetic Fields journal, February 2001

129 Xe and 1 H NMR Study of the Reversible Trapping of Xenon by Cryptophane-A in Organic Solution journal, February 1998

Imaging with intermolecular multiple-quantum coherences in solution nuclear magnetic resonance journal, February 1995

Nuclear magnetic relaxation of the 129 Xe and 131 Xe isotopes of xenon gas dissolved in isotropic and anisotropic liquids journal, July 1990

Mapping of metabolites in whole animals by 31P NMR using surface coils journal, January 1980

Biological magnetic resonance imaging using laser-polarized 129Xe journal, July 1994

Structural origins of high-affinity biotin binding to streptavidin journal, January 1989

Multiple echoes initiated by a single radio frequency pulse in NMR journal, November 1998

Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme journal, September 2000

Hyperpolarized Gases Set NMR World Spinning: Chemical applications of laser polarization include improved NMR sensitivity journal, December 1996

129 Xe NMR Spectroscopy of Metal Carbonyl Clusters and Metal Clusters in Zeolite NaY journal, August 1999

Possibilities for high-resolution nuclear magnetic resonance spectra of crystals journal, January 1962

Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides: DETERMINANTS OF SPECIFICITY AND UTILITY IN ASSAYS OF RECEPTOR FUNCTION journal, April 2000

Evidence of xenon transport through the gramicidin channel: a 129Xe-NMR study journal, July 1994

Cross polarization from laser-polarized solid xenon to 13CO2 by low-field thermal mixing journal, April 1993

High-resolution NMR in inhomogeneous fields journal, October 1997

Spin transfer between laser-polarized 129Xe nuclei and surface protons journal, December 1993

Cyclotriveratrylenes and cryptophanes journal, January 1987

Conformational Changes of Three Periplasmic Receptors for Bacterial Chemotaxis and Transport: The Maltose-, Glucose/Galactose- and Ribose-binding Proteins. journal, November 1996

Synthesis and exciton optical activity of D3-cryptophanes journal, October 1987

Intracellular calcium measurements by 19F NMR of fluorine-labeled chelators. journal, December 1983

Surface Relaxation Mechanisms of Laser-Polarized 129 Xe journal, June 1995

The Nutation Spin Echo and Its Use for Localized NMR journal, September 2000

Cavities in proteins: structure of a metmyoglobin xenon complex solved to 1.9 .ANG. journal, June 1984

An NMR study of ligand binding by maltodextrin binding protein journal, May 1998

[3] Applications of avidin-biotin technology: Literature survey book, January 1990

FLASH imaging. Rapid NMR imaging using low flip-angle pulses journal, April 1986

Experimental Verification of the Overhauser Nuclear Polarization Effect journal, May 1956

Two new abnormal pathways in the para-Claisen rearrangement of 2(allyloxy)- and 2-(crotyloxy)-3-hydroxybenzaldehyde
journal, March 1991

Enhancement of Solution NMR and MRI with Laser-Polarized Xenon
journal, March 1996

Optical Pumping
journal, August 1963

Discovering High-Affinity Ligands for Proteins: SAR by NMR
journal, November 1996

The NMR-mouse: construction, excitation, and applications
journal, June 1998

Spin-polarized xenon-129 NMR study of a polymer surface
journal, February 1993

Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
journal, August 1997

¹²⁹ Xe NMR Spectroscopy of Deuterium-Labeled Cryptophane-A Xenon Complexes: Investigation of Host−Guest Complexation Dynamics
journal, February 2000

Polarization of Nuclei in Metals
journal, October 1953

Low field magnetic resonance images of polarized noble gases obtained with a dc superconducting quantum interference device
journal, April 1998

Spin-lattice relaxation of laser-polarized xenon in human blood
journal, March 1999

Nuclear Magnetic Resonance Spectroscopy in the Earth Sciences: Structure and Dynamics
journal, July 1989

Isolation and characterization of a thermostable aminopeptidase(aminopeptidase T) from Thermus aquaticus YT-1, an extremely thermophilic bacterium.
journal, January 1988

In SituNMR Analysis of Fluids Contained in Sedimentary Rock
journal, August 1998

Approach to High-Resolution ex Situ NMR Spectroscopy
journal, July 2001

Voltage-sensitive magnetic gels as magnetic resonance monitoring agents
journal, May 1993

NMR of laser-polarized xenon in human blood
journal, November 1996

Evidence of nonspecific surface interactions between laser-polarized xenon and myoglobin in solution
journal, August 2000

Fluorescence polarization — a new tool for cell and molecular biology
journal, May 1995

Selective Enhancement of NMR Signals forα-Cyclodextrin with Laser-Polarized Xenon
journal, November 1997

Temperature-dependent molecular motions of cholesterol esters: a carbon-13 nuclear magnetic resonance study
journal, December 1982

Nuclear magnetic resonance studies of xenon-129 with myoglobin and hemoglobin
journal, December 1982

Binding of Xenon to Sperm Whale Myoglobin
journal, July 1965

Hyperpolarized129Xe NMR as a probe for blood oxygenation
journal, April 2000

Exploring Surfaces and Cavities in Lipoxygenase and Other Proteins by Hyperpolarized Xenon-129 NMR
journal, September 1999

High-field NMR of adsorbed xenon polarized by laser pumping
journal, February 1991

Xenon NMR: chemical shifts of a general anesthetic in common solvents, proteins, and membranes.
journal, August 1981

Introduction
book, January 1971

Spin Dynamics of Carr–Purcell–Meiboom–Gill-like Sequences in Grossly Inhomogeneous B0 and B1 Fields and Application to NMR Well Logging
journal, March 2000

In vivo magnetic resonance vascular imaging using laser-polarized 3He microbubbles
journal, September 1998

Study of Xenon Binding in Cryptophane-A Using Laser-Induced NMR Polarization Enhancement
journal, April 1999

Biospecific interaction analysis using biosensor technology
journal, January 1993

Nuclear magnetic relaxation of Xenon-129 dissolved in organic solvents
journal, December 1991

Measurement of high-resolution NMR spectra in an inhomogeneous magnetic field
journal, November 1987

Magnetization transfer from laser-polarized xenon to protons located in the hydrophobic cavity of the wheat nonspecific lipid transfer protein
journal, April 2001

High-resolution NMR spectra in inhomogeneous magnetic fields: application of total spin coherence transfer echoes
journal, June 1981

High-field cross polarization NMR from laser-polarized xenon to a polymer surface
journal, September 1993

Spin-exchange optical pumping of noble-gas nuclei
journal, April 1997

Relaxation Processes in a System of Two Spins
journal, July 1955

Spin-Polarized 129Xe Gas Imaging of Materials
journal, July 1995

Some Developments in Nuclear Magnetic Resonance of Solids
journal, October 1989

Maltose Transport in Escherichia coli K12. A Comparison of Transport Kinetics in Wild-Type and lamba-Resistant Mutants with the Dissociation Constants of the Maltose-Binding Protein as Measured by Fluorescence Quenching
journal, May 1976

MR Imaging with Hyperpolarized3He Gas
journal, February 1995

Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms
journal, June 1984

Production of Thermostable Alkaline Proteases by Thermophilic Streptomyces
journal, January 1969

In vivo visualization of gene expression using magnetic resonance imaging
journal, March 2000

NMR of optically pumped xenon thin films
journal, April 1992

Nuclear Magnetic Resonance Spectra from a Crystal rotated at High Speed
journal, December 1958

Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis
journal, November 1992

Diffusion Measurements with the Aid of Nutation Spin Echoes Appearing after Two Inhomogeneous Radiofrequency Pulses in Inhomogeneous Magnetic Fields
journal, February 2001

129 Xe and 1 H NMR Study of the Reversible Trapping of Xenon by Cryptophane-A in Organic Solution
journal, February 1998

Imaging with intermolecular multiple-quantum coherences in solution nuclear magnetic resonance
journal, February 1995

Nuclear magnetic relaxation of the 129 Xe and 131 Xe isotopes of xenon gas dissolved in isotropic and anisotropic liquids
journal, July 1990

Mapping of metabolites in whole animals by 31P NMR using surface coils
journal, January 1980

Biological magnetic resonance imaging using laser-polarized 129Xe
journal, July 1994

Structural origins of high-affinity biotin binding to streptavidin
journal, January 1989

Multiple echoes initiated by a single radio frequency pulse in NMR
journal, November 1998

Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme
journal, September 2000

Hyperpolarized Gases Set NMR World Spinning: Chemical applications of laser polarization include improved NMR sensitivity
journal, December 1996

¹²⁹ Xe NMR Spectroscopy of Metal Carbonyl Clusters and Metal Clusters in Zeolite NaY
journal, August 1999

Possibilities for high-resolution nuclear magnetic resonance spectra of crystals
journal, January 1962

Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides: DETERMINANTS OF SPECIFICITY AND UTILITY IN ASSAYS OF RECEPTOR FUNCTION
journal, April 2000

Evidence of xenon transport through the gramicidin channel: a 129Xe-NMR study
journal, July 1994

Cross polarization from laser-polarized solid xenon to 13CO2 by low-field thermal mixing
journal, April 1993

High-resolution NMR in inhomogeneous fields
journal, October 1997

Spin transfer between laser-polarized 129Xe nuclei and surface protons
journal, December 1993

Cyclotriveratrylenes and cryptophanes
journal, January 1987

Conformational Changes of Three Periplasmic Receptors for Bacterial Chemotaxis and Transport: The Maltose-, Glucose/Galactose- and Ribose-binding Proteins.
journal, November 1996

Synthesis and exciton optical activity of D3-cryptophanes
journal, October 1987

Intracellular calcium measurements by 19F NMR of fluorine-labeled chelators.
journal, December 1983

Surface Relaxation Mechanisms of Laser-Polarized $^{129} Xe$
journal, June 1995

The Nutation Spin Echo and Its Use for Localized NMR
journal, September 2000

Cavities in proteins: structure of a metmyoglobin xenon complex solved to 1.9 .ANG.
journal, June 1984

An NMR study of ligand binding by maltodextrin binding protein
journal, May 1998

[3] Applications of avidin-biotin technology: Literature survey
book, January 1990

FLASH imaging. Rapid NMR imaging using low flip-angle pulses
journal, April 1986

Experimental Verification of the Overhauser Nuclear Polarization Effect
journal, May 1956

Chemistry: "Amplifying" the Fine Details of Molecular Structure Is a Gas
journal, March 1996

Efficiency of Spin Exchange between Rubidium Spins and ${}^{129}{Xe}$ Nuclei in a Gas
journal, July 1982

NMR chemical shift of xenon-129 dissolved in polymers
journal, October 1993