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Title: Gene targets for improved enzyme production in fungi

Abstract

Fungi that are genetically inactivated for the mstC gene (or a homolog thereof) are provided, which can also be genetically modified to increase production of heterologous proteins from a glucoamylase promoter. Methods of using these fungi, for example to degrade a biomass, are also provided.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1805568
Patent Number(s):
10934551
Application Number:
16/163,509
Assignee:
Battelle Memorial Institute (Richland, WA); National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
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DOE Contract Number:  
AC02-05CH11231; AC05-76RL01830
Resource Type:
Patent
Resource Relation:
Patent File Date: 10/17/2018
Country of Publication:
United States
Language:
English

Citation Formats

Baker, Scott E., Magnuson, Jon K., Reilly, Mike C., Kim, Joonhoon, Gladden, John M., and Lynn, Joe J. Gene targets for improved enzyme production in fungi. United States: N. p., 2021. Web.
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Baker, Scott E., Magnuson, Jon K., Reilly, Mike C., Kim, Joonhoon, Gladden, John M., & Lynn, Joe J. Gene targets for improved enzyme production in fungi. United States.
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Baker, Scott E., Magnuson, Jon K., Reilly, Mike C., Kim, Joonhoon, Gladden, John M., and Lynn, Joe J. Tue . "Gene targets for improved enzyme production in fungi". United States. https://www.osti.gov/servlets/purl/1805568.
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@article{osti_1805568,
title = {Gene targets for improved enzyme production in fungi},
author = {Baker, Scott E. and Magnuson, Jon K. and Reilly, Mike C. and Kim, Joonhoon and Gladden, John M. and Lynn, Joe J.},
abstractNote = {Fungi that are genetically inactivated for the mstC gene (or a homolog thereof) are provided, which can also be genetically modified to increase production of heterologous proteins from a glucoamylase promoter. Methods of using these fungi, for example to degrade a biomass, are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 02 00:00:00 EST 2021},
month = {Tue Mar 02 00:00:00 EST 2021}
}
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Works referenced in this record:

Ionic Liquid-Tolerant Cellulase Enzymes
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