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Title: Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma

Abstract

A method for treatment of breast cancer and other types of cancer. The method comprises targeting and modulating Id-1 gene expression, if any, for the Id-1 gene, or gene products in breast or other epithelial cancers in a patient by delivering products that modulate Id-1 gene expression. When expressed, Id-1 gene is a prognostic indicator that cancer cells are invasive and metastatic.

Inventors:
;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1150642
Patent Number(s):
8809291
Application Number:
13/252,148
Assignee:
California Pacific Medical Center Research Institute (San Francisco, CA); The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
AC03-765F00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Desprez, Pierre-Yves, and Campisi, Judith. Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma. United States: N. p., 2014. Web.
Desprez, Pierre-Yves, & Campisi, Judith. Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma. United States.
Desprez, Pierre-Yves, and Campisi, Judith. Tue . "Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma". United States. https://www.osti.gov/servlets/purl/1150642.
@article{osti_1150642,
title = {Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma},
author = {Desprez, Pierre-Yves and Campisi, Judith},
abstractNote = {A method for treatment of breast cancer and other types of cancer. The method comprises targeting and modulating Id-1 gene expression, if any, for the Id-1 gene, or gene products in breast or other epithelial cancers in a patient by delivering products that modulate Id-1 gene expression. When expressed, Id-1 gene is a prognostic indicator that cancer cells are invasive and metastatic.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {8}
}

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Works referenced in this record:

The helix-loop-helix transcription factor, Id-1, is overexpressed in medullary thyroid cancer
journal, December 2000


Id-1 and Id-2 Are Overexpressed in Pancreatic Cancer and in Dysplastic Lesions in Chronic Pancreatitis
journal, September 1999


A Novel Pathway for Mammary Epithelial Cell Invasion Induced by the Helix-Loop-Helix Protein Id-1
journal, August 1998