Formation of stable submicron peptide or protein particles by thin film freezing

Johnston, Keith P.; Engstrom, Joshua; Williams, Robert O.

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Title: Formation of stable submicron peptide or protein particles by thin film freezing

Abstract

The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm.sup.-1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30.degree. C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm.sup.-1.

Inventors:: Johnston, Keith P.; Engstrom, Joshua; Williams, III, Robert O.

Issue Date:: Tue Apr 18 00:00:00 EDT 2017

Research Org.:: Board of Regents, The University of Texas System, Austin, TX (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1351888

Patent Number(s):: 9622974

Application Number:: 14/603,211

Assignee:: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K9/1658 - {Proteins, e.g. albumin, gelatin}
A61K9/1682 - {Processes}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P15/10 - for impotence
A61P25/16 - Anti-Parkinson drugs
A61P25/34 - Tobacco-abuse
A61P3/10 - for hyperglycaemia, e.g. antidiabetics
A61P35/00 - Antineoplastic agents
A61P7/02 - Antithrombotic agents
A61P9/12 - Antihypertensives

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D9/005 - {Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T428/2982 - Particulate matter [e.g., sphere, flake, etc.]

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DOE Contract Number:: FG02-04ER15549

Resource Type:: Patent

Resource Relation:: Patent File Date: 2015 Jan 22

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 36 MATERIALS SCIENCE

Citation Formats


                    Johnston, Keith P., Engstrom, Joshua, and Williams, III, Robert O. Formation of stable submicron peptide or protein particles by thin film freezing.  United States: N. p., 2017. 
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                    Johnston, Keith P., Engstrom, Joshua, & Williams, III, Robert O. Formation of stable submicron peptide or protein particles by thin film freezing.  United States.

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                    Johnston, Keith P., Engstrom, Joshua, and Williams, III, Robert O. Tue .  
        "Formation of stable submicron peptide or protein particles by thin film freezing".  United States.  https://www.osti.gov/servlets/purl/1351888.

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@article{osti_1351888,

  title        = {Formation of stable submicron peptide or protein particles by thin film freezing},

  author       = {Johnston, Keith P. and Engstrom, Joshua and Williams, III, Robert O.},

  abstractNote = {The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm.sup.-1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30.degree. C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm.sup.-1.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Apr 18 00:00:00 EDT 2017},

  month        = {Tue Apr 18 00:00:00 EDT 2017}

}

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