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Title: Formation of stable submicron peptide or protein particles by thin film freezing

Patent ·
OSTI ID:1568314
; ;

The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.

Research Organization:
Univ. of Texas, Austin, TX (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-04ER15549
Assignee:
Board of Regents, The University of Texas System (Austin, TX)
Patent Number(s):
10,285,945
Application Number:
15/479,137
OSTI ID:
1568314
Resource Relation:
Patent File Date: 04/04/2017
Country of Publication:
United States
Language:
English

References (51)

Ophthalmological composition of the type which undergoes liquid-gel phase transition patent August 1989
Method for delivering drugs to the brain patent-application March 2005
Highly pseudoplastic polymer solutions patent June 1986
Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle patent August 2007
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions patent May 1993
Methods of Processing Compositions Containing Microparticles patent-application February 2010
Antibody-containing particles and compositions patent-application March 2005
Injectable extended release formulations and methods patent October 1994
Compositions and Methods for Drug Delivery patent-application November 2009
Solvent/polymer solutions as suspension vehicles patent-application August 2006
Pharmaceutical composition in gel form in a dispensing package patent April 1994
Protein Microspheres Retaining Pharmacokinetic and Pharmacodynamic Properties patent-application September 2007
Method of preparing a drug delivery system comprising a drug and a gel using a syringe patent March 1997
Erosion rate modifier for use in bioerodible drug delivery devices and method of use patent November 1996
Lyophilised Antibody Formulation patent-application September 2010
Modified-release microparticles based on amphiphilic copolymer and on active principles(s) and pharmaceutical formulations comprising them patent-application May 2008
Injectable Oily Peptide Preparations and Processes for Their Manufacture patent March 1975
Methods of producing nucleic acid ligands patent January 1997
Systematic evolution of ligands by exponential enrichment: chimeric selex patent June 1997
Low Viscosity Concentrated Protein Dispersions patent-application March 2016
Viscous suspensions of controlled-release drug particles patent July 1996
Use of carrageenans in topical ophthalmic compositions patent April 1995
Stable flowable protein and nucleic acid formulations using non-aqueous, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity patent-application August 2004
Protein microspheres having injectable properties at high concentrations patent-application February 2006
Method to obtain microparticles containing an H+,K+-ATPase inhibitor patent-application July 2006
Cosmetic and pharmaceutical vehicle thickened with solid emulsifier patent January 1982
Formation of Stable Submicron Peptide or Protein Particles by Thin Film Freezing patent-application September 2010
Droplet freezing method and apparatus patent July 1989
Use of microparticles combined with submicron oil-in-water emulsions patent-application April 2009
Production of microspheres patent May 2008
Formation of stable submicron peptide or protein particles by thin film freezing patent March 2015
Protein Formulation patent-application June 2010
Low Viscosity Highly Concentrated Suspensions patent-application December 2014
Non-covalent modification of microparticles and process of preparing same patent-application January 2010
Protein Nanoparticle Dispersions patent-application September 2012
High concentration antibody and protein formulations patent-application October 2004
Sustained release, comfort formulation for glaucoma therapy patent March 1990
Method for identifying an oligonucleotide aptamer specific for a target patent December 1996
Complexation of metal ions with polypeptides patent-application January 2007
Pseudoplastic gel transfer patent May 1986
Protein nanoparticles patent-application July 2009
Process for production of nanoparticles and microparticles by spray freezing into liquid patent-application February 2004
Protein Nanoparticles and the Use of the Same patent-application December 2009
Oral sustained release drug delivery device patent April 1996
Protein formulation patent July 2001
Nanoparticle compositions of water-soluble drugs for oral administration and preparation methods thereof patent-application July 2007
Nanoclusters for delivery of therapeutics patent January 2010
Spherical protein particles and methods for making and using them patent August 2011
Prolonged release of biologically active somatotropin patent May 1995
Pharmaceutical formulation patent June 1997
Low viscosity highly concentrated suspensions patent July 2014

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