Formation of stable submicron peptide or protein particles by thin film freezing

Patent · 26 January 2021

OSTI ID:1805410

Johnston, Keith P.; Engstrom, Joshua; Williams, III, Robert O.

The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.

• Research Organization: Univ. of Texas, Austin, TX (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: FG02-04ER15549
• Assignee: Board of Regents, The University of Texas System (Austin, TX)
• Patent Number(s): 10,898,437
• Application Number: 16/410,189
• OSTI ID: 1805410
• Country of Publication: United States
• Language: English