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Title: Formation of stable submicron peptide or protein particles by thin film freezing

Abstract

The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.

Inventors:
; ;
Issue Date:
Research Org.:
Univ. of Texas, Austin, TX (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1568314
Patent Number(s):
10285945
Application Number:
15/479,137
Assignee:
Board of Regents, The University of Texas System (Austin, TX)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
FG02-04ER15549
Resource Type:
Patent
Resource Relation:
Patent File Date: 04/04/2017
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Johnston, Keith P., Engstrom, Joshua, and Williams, III, Robert O. Formation of stable submicron peptide or protein particles by thin film freezing. United States: N. p., 2019. Web.
Johnston, Keith P., Engstrom, Joshua, & Williams, III, Robert O. Formation of stable submicron peptide or protein particles by thin film freezing. United States.
Johnston, Keith P., Engstrom, Joshua, and Williams, III, Robert O. Tue . "Formation of stable submicron peptide or protein particles by thin film freezing". United States. https://www.osti.gov/servlets/purl/1568314.
@article{osti_1568314,
title = {Formation of stable submicron peptide or protein particles by thin film freezing},
author = {Johnston, Keith P. and Engstrom, Joshua and Williams, III, Robert O.},
abstractNote = {The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {5}
}

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