Formation of stable submicron peptide or protein particles by thin film freezing
Abstract
The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of Texas, Austin, TX (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1568314
- Patent Number(s):
- 10285945
- Application Number:
- 15/479,137
- Assignee:
- Board of Regents, The University of Texas System (Austin, TX)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- DOE Contract Number:
- FG02-04ER15549
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 04/04/2017
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Johnston, Keith P., Engstrom, Joshua, and Williams, III, Robert O. Formation of stable submicron peptide or protein particles by thin film freezing. United States: N. p., 2019.
Web.
Johnston, Keith P., Engstrom, Joshua, & Williams, III, Robert O. Formation of stable submicron peptide or protein particles by thin film freezing. United States.
Johnston, Keith P., Engstrom, Joshua, and Williams, III, Robert O. Tue .
"Formation of stable submicron peptide or protein particles by thin film freezing". United States. https://www.osti.gov/servlets/purl/1568314.
@article{osti_1568314,
title = {Formation of stable submicron peptide or protein particles by thin film freezing},
author = {Johnston, Keith P. and Engstrom, Joshua and Williams, III, Robert O.},
abstractNote = {The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {5}
}
Works referenced in this record:
Ophthalmological composition of the type which undergoes liquid-gel phase transition
patent, August 1989
- Mazuel, Claude; Friteyre, Marie-Claire
- US Patent Document 4,861,760
Highly pseudoplastic polymer solutions
patent, June 1986
- Greminger, Jr., George K.; Dehnke, Mary K.
- US Patent Document 4,594,108
Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
patent, August 2007
- Berry, Stephen A.; Fereira, Pamela J.; Dehnad, Houdin
- US Patent Document 7,258,869
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
patent, May 1993
- Missel, Paul J.; Lang, John C.; Jani, Rajni
- US Patent Document 5,212,162
Injectable extended release formulations and methods
patent, October 1994
- Brooks, Norman D.; Needham, Gregory F.
- US Patent Document 5,352,662
Pharmaceutical composition in gel form in a dispensing package
patent, April 1994
- Tachon, Pierre; Vagneur, Beatrice; Viret, Jean-Louis
- US Patent Document 5,300,302
Method of preparing a drug delivery system comprising a drug and a gel using a syringe
patent, March 1997
- Fjellstrom, Torsten
- US Patent Document 5,614,221
Erosion rate modifier for use in bioerodible drug delivery devices and method of use
patent, November 1996
- Roorda, Wouter E.; Ehnow, Fred P.
- US Patent Document 5,571,525
Methods of producing nucleic acid ligands
patent, January 1997
- Gold, Larry M.; Tuerk, Craig
- US Patent Document 5,595,877
Systematic evolution of ligands by exponential enrichment: chimeric selex
patent, June 1997
- Burke, Donald S.; Tarasow, Ted; Eaton, Bruce E.
- US Patent Document 5,637,459
Viscous suspensions of controlled-release drug particles
patent, July 1996
- Roorda, Wouter E.; Ehnow, Fred P.
- US Patent Document 5,540,912
Use of carrageenans in topical ophthalmic compositions
patent, April 1995
- Lang, John C.; Keister, Jamieson C.; Missel, Paul J.
- US Patent Document 5,403,841
Cosmetic and pharmaceutical vehicle thickened with solid emulsifier
patent, January 1982
- Chang, Tiang-Shing; Zientek, Lucy J.
- US Patent Document 4,310,516
Droplet freezing method and apparatus
patent, July 1989
- Davis, Robert B.; DeVack, Donald Leonard
- US Patent Document 4,848,094
Formation of stable submicron peptide or protein particles by thin film freezing
patent, March 2015
- Johnston, Keith P.; Engstrom, Joshua; Williams, III, Robert O.
- US Patent Document 8,968,786
Sustained release, comfort formulation for glaucoma therapy
patent, March 1990
- Jani, Rajni; Harris, Robert G.
- US Patent Document 4,911,920
Method for identifying an oligonucleotide aptamer specific for a target
patent, December 1996
- Toole, Jr., John J.; Latham, John A.; Bock, Louis C.
- US Patent Document 5,582,981
Oral sustained release drug delivery device
patent, April 1996
- Landrau, Felix A.; Campbell, Patricia S.; Hall, Arthur W.
- US Patent Document 5,512,293
Protein formulation
patent, July 2001
- Andya, James; Cleland, Jeffrey L.; Hsu, Chung C.
- US Patent Document 6,267,958
Nanoclusters for delivery of therapeutics
patent, January 2010
- Berkland, Cory J.; Shi, Lianjun
- US Patent Document 7,651,770
Spherical protein particles and methods for making and using them
patent, August 2011
- Yakovlevsky, Kirill; Shamashkin, Michael; Khalaf, Nazer K.
- US Patent Document 7,998,477
Prolonged release of biologically active somatotropin
patent, May 1995
- Mitchell, James W.
- US Patent Document 5,411,951
Pharmaceutical formulation
patent, June 1997
- Nystrom, Christer; Paalzow, Lennart; Aquilonius, Sten-Magnus
- US Patent Document 5,635,213
Low viscosity highly concentrated suspensions
patent, July 2014
- Johnston, Keith P.; Mazuski, Maria Andrea; Engstrom, Joshua
- US Patent Document 8,779,094