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Title: Apparatus and method for performing microfluidic manipulations for chemical analysis

Abstract

A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolitographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.

Inventors:
 [1]
  1. Knoxville, TN
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
OSTI Identifier:
874215
Patent Number(s):
6342142
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
apparatus; method; performing; microfluidic; manipulations; chemical; analysis; microchip; provide; fluidic; variety; applications; including; sample; injection; liquid; chromatography; fabricated; standard; photolitographic; procedures; wet; etching; substrate; cover; plate; joined; direct; bonding; capillary; electrophoresis; performed; channels; formed; injections; electro-osmotically; pumping; channel; crosses; separation; followed; switching; potentials; force; plug; wet etching; liquid chromatograph; microfluidic manipulations; performing microfluidic; including sample; provide fluid; /204/422/

Citation Formats

Ramsey, J Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis. United States: N. p., 2002. Web.
Ramsey, J Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis. United States.
Ramsey, J Michael. Tue . "Apparatus and method for performing microfluidic manipulations for chemical analysis". United States. https://www.osti.gov/servlets/purl/874215.
@article{osti_874215,
title = {Apparatus and method for performing microfluidic manipulations for chemical analysis},
author = {Ramsey, J Michael},
abstractNote = {A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolitographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

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Works referenced in this record:

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