Apparatus and method for performing microfluidic manipulations for chemical analysis

Ramsey, J Michael

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A - human necessities
A01 - agriculture
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B01 - physical or chemical processes or apparatus in general
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Title: Apparatus and method for performing microfluidic manipulations for chemical analysis

Abstract

A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolitographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.

Inventors:

Ramsey, J Michael ^[1]

Knoxville, TN

Issue Date:: Tue Jan 01 00:00:00 EST 2002

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:: 874215

Patent Number(s):: 6342142

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D15/3842 - {Micellar chromatography}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J19/0093 - {Microreactors, e.g. miniaturised or microfabricated reactors
B01J2219/00783 - Laminate assemblies, i.e. the reactor comprising a stack of plates
B01J2219/00826 - Quartz
B01J2219/00828 - Silicon wafers or plates
B01J2219/00831 - Glass
B01J2219/00853 - Employing electrode arrangements
B01J2219/00889 - Mixing
B01J2219/00891 - Feeding or evacuation
B01J2219/00912 - by electrophoresis
B01J2219/00916 - by chromatography
B01J2219/00952 - Sensing operations
B01J2219/0097 - Optical sensors
B01J2219/00995 - Mathematical modeling

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L2200/0605 - Metering of fluids
B01L2300/0816 - Cards, e.g. flat sample carriers usually with flow in two horizontal directions
B01L2300/0867 - Multiple inlets and one sample wells, e.g. mixing, dilution
B01L2300/0883 - Serpentine channels
B01L2400/0415 - electrical forces, e.g. electrokinetic
B01L2400/0418 - electro-osmotic flow [EOF]
B01L2400/0421 - electrophoretic flow
B01L3/5027 - {by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
B01L3/502715 - {characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces}
B01L3/50273 - {characterised by the means or forces applied to move the fluids
B01L3/502738 - {characterised by integrated valves
B01L3/502753 - {characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
B01L3/502776 - {specially adapted for focusing or laminating flows}
B01L3/502784 - {specially adapted for droplet or plug flow, e.g. digital microfluidics

B - PERFORMING OPERATIONS B29 - WORKING OF PLASTICS B29C - SHAPING OR JOINING OF PLASTICS
B29C65/4895 - {Solvent bonding, i.e. the surfaces of the parts to be joined being treated with solvents, swelling or softening agents, without adhesives}
B29C66/026 - {Chemical pre-treatments
B29C66/034 - {Thermal after-treatments}
B29C66/54 - {Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N2030/027 - {Liquid chromatography}
G01N2030/162 - {electromigration}
G01N2030/285 - {electrically driven carrier}
G01N2030/383 - {by using auxiliary fluid}
G01N2030/8435 - {for chemical reaction}
G01N27/44743 - {Introducing samples}
G01N27/44791 - {Microapparatus
G01N30/02 - Column chromatography
G01N30/16 - Injection
G01N30/6095 - {Micromachined or nanomachined, e.g. micro- or nanosize}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S366/01 - Micromixers

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DOE Contract Number:: AC05-84OR21400

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: apparatus; method; performing; microfluidic; manipulations; chemical; analysis; microchip; provide; fluidic; variety; applications; including; sample; injection; liquid; chromatography; fabricated; standard; photolitographic; procedures; wet; etching; substrate; cover; plate; joined; direct; bonding; capillary; electrophoresis; performed; channels; formed; injections; electro-osmotically; pumping; channel; crosses; separation; followed; switching; potentials; force; plug; wet etching; liquid chromatograph; microfluidic manipulations; performing microfluidic; including sample; provide fluid; /204/422/

Citation Formats


                    Ramsey, J Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis.  United States: N. p., 2002. 
        Web.

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                    Ramsey, J Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis.  United States.

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                    Ramsey, J Michael. Tue .  
        "Apparatus and method for performing microfluidic manipulations for chemical analysis".  United States.  https://www.osti.gov/servlets/purl/874215.

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@article{osti_874215,

  title        = {Apparatus and method for performing microfluidic manipulations for chemical analysis},

  author       = {Ramsey, J Michael},

  abstractNote = {A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolitographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jan 01 00:00:00 EST 2002},

  month        = {Tue Jan 01 00:00:00 EST 2002}

}

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Works referenced in this record:

Planar chips technology for miniaturization and integration of separation techniques into monitoring systems
journal, February 1992

Manz, Andreas; Harrison, D. Jed; Verpoorte, Elisabeth M. J.
Journal of Chromatography A, Vol. 593, Issue 1-2
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High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device
journal, September 1994

Effenhauser, Carlo S.; Paulus, Aran.; Manz, Andreas.
Analytical Chemistry, Vol. 66, Issue 18
https://doi.org/10.1021/ac00090a024

Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights
journal, October 1993

Effenhauser, Carlo S.; Manz, Andreas.; Widmer, H. Michael.
Analytical Chemistry, Vol. 65, Issue 19
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Electric sample splitter for capillary zone electrophoresis
journal, February 1985

Deml, M.; Foret, F.; Boček, P.
Journal of Chromatography A, Vol. 320, Issue 1
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A novel approach to ion separations in solution: synchronized cyclic capillary electrophoresis (SCCE)
journal, June 1994

Burggraf, Norbert; Manz, Andreas; Verpoorte, Elisabeth
Sensors and Actuators B: Chemical, Vol. 20, Issue 2-3
https://doi.org/10.1016/0925-4005(93)01200-N

Synchronized cyclic capillary electrophores—a novel approach to ion separations in solution
journal, October 1993

Burggraf, Norbert; Manz, Andreas; Effenhauser, Carlo S.
Journal of High Resolution Chromatography, Vol. 16, Issue 10
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Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices
journal, April 1994

Jacobson, Stephen C.; Hergenroder, Roland.; Koutny, Lance B.
Analytical Chemistry, Vol. 66, Issue 7
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Electrically Driven Separations on a Microship
conference, June 1994

Jacobsen, S. C.; Gergenroeder, R.; Moore, A. W.
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Towards miniaturized electrophoresis and chemical analysis systems on silicon: an alternative to chemical sensors
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Harrison, D. Jed; Glavina, P. G.; Manz, Andreas
Sensors and Actuators B: Chemical, Vol. 10, Issue 2
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Electroosmotic Pumping and Valveless Control of Fluid Flow within a Manifold of Capillaries on a Glass Chip
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Seiler, Kurt.; Fan, Zhonghui H.; Fluri, Karl.
Analytical Chemistry, Vol. 66, Issue 20
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Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip
journal, August 1993

Harrison, D. J.; Fluri, K.; Seiler, K.
Science, Vol. 261, Issue 5123
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Open Channel Electrochromatography on a Microchip
journal, July 1994

Jacobson, Stephen C.; Hergenroeder, Roland.; Koutny, Lance B.
Analytical Chemistry, Vol. 66, Issue 14
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Capillary electrophoresis and sample injection systems integrated on a planar glass chip
journal, September 1992

Harrison, D. Jed.; Manz, Andreas.; Fan, Zhonghui.
Analytical Chemistry, Vol. 64, Issue 17
https://doi.org/10.1021/ac00041a030

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Similar Records

Title: Apparatus and method for performing microfluidic manipulations for chemical analysis

Abstract

Citation Formats

Planar chips technology for miniaturization and integration of separation techniques into monitoring systems journal, February 1992

High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device journal, September 1994

Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights journal, October 1993

Electric sample splitter for capillary zone electrophoresis journal, February 1985

A novel approach to ion separations in solution: synchronized cyclic capillary electrophoresis (SCCE) journal, June 1994

Synchronized cyclic capillary electrophores—a novel approach to ion separations in solution journal, October 1993

Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices journal, April 1994

Electrically Driven Separations on a Microship conference, June 1994

Towards miniaturized electrophoresis and chemical analysis systems on silicon: an alternative to chemical sensors journal, January 1993

Electroosmotic Pumping and Valveless Control of Fluid Flow within a Manifold of Capillaries on a Glass Chip journal, October 1994

Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip journal, August 1993

Open Channel Electrochromatography on a Microchip journal, July 1994

Capillary electrophoresis and sample injection systems integrated on a planar glass chip journal, September 1992

Planar chips technology for miniaturization and integration of separation techniques into monitoring systems
journal, February 1992

High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device
journal, September 1994

Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights
journal, October 1993

Electric sample splitter for capillary zone electrophoresis
journal, February 1985

A novel approach to ion separations in solution: synchronized cyclic capillary electrophoresis (SCCE)
journal, June 1994

Synchronized cyclic capillary electrophores—a novel approach to ion separations in solution
journal, October 1993

Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices
journal, April 1994

Electrically Driven Separations on a Microship
conference, June 1994

Towards miniaturized electrophoresis and chemical analysis systems on silicon: an alternative to chemical sensors
journal, January 1993

Electroosmotic Pumping and Valveless Control of Fluid Flow within a Manifold of Capillaries on a Glass Chip
journal, October 1994

Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip
journal, August 1993

Open Channel Electrochromatography on a Microchip
journal, July 1994

Capillary electrophoresis and sample injection systems integrated on a planar glass chip
journal, September 1992