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Title: Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

Abstract

A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.

Inventors:
 [1]
  1. Knoxville, TN
Publication Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
OSTI Identifier:
872093
Patent Number(s):
US 5858195
Assignee:
Lockheed Martin Energy Research Corporation (Oak Ridge, TN)
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
apparatus; method; performing; microfluidic; manipulations; chemical; analysis; synthesis; microchip; laboratory; provide; fluid; variety; applications; including; sample; injection; separations; fabricated; standard; photolithographic; procedures; wet; etching; substrate; cover; plate; joined; direct; bonding; capillary; electrophoresis; electrochromatography; performed; channels; formed; analytes; loaded; four-way; intersection; electrokinetically; pumping; analyte; followed; switching; potentials; force; plug; separation; channel; chemical separations; separation channel; chemical wet; performing microfluidic; microfluidic manipulations; photolithographic procedures; plate joined; standard photolithographic; channels formed; chemical analysis; capillary electrophoresis; cover plate; sample injection; method provide; wet etching; provide fluid; microchip chemical; microchip laboratory; direct bonding; including sample; electrokinetically pumping; fluid manipulations; four-way intersection; analyte plug; chemical separation; fluidic manipulations; lithographic procedures; /204/

Citation Formats

Ramsey, J Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis. United States: N. p., 1999. Web.
Ramsey, J Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis. United States.
Ramsey, J Michael. 1999. "Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis". United States. https://www.osti.gov/servlets/purl/872093.
@article{osti_872093,
title = {Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis},
author = {Ramsey, J Michael},
abstractNote = {A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.},
doi = {},
url = {https://www.osti.gov/biblio/872093}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}

Works referenced in this record:

Electroosmosis: A Reliable Fluid Propulsion System for Flow Injection Analysis
journal, June 1994


Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights
journal, October 1993


Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation, and separation efficiency
journal, May 1993


Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices
journal, April 1994


Electric sample splitter for capillary zone electrophoresis
journal, February 1985


High-Speed Separations on a Microchip
journal, April 1994


Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip
journal, August 1993


Capillary electrophoresis and sample injection systems integrated on a planar glass chip
journal, September 1992