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Title: Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

Abstract

A microchip laboratory system and method proved fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.

Inventors:
 [1]
  1. Knoxville, TN
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
OSTI Identifier:
872793
Patent Number(s):
6010608
Assignee:
Lockheed Martin Energy Research Corporation (Oak Ridge, TN)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
apparatus; method; performing; microfluidic; manipulations; chemical; analysis; synthesis; microchip; laboratory; proved; fluid; variety; applications; including; sample; injection; separations; fabricated; standard; photolithographic; procedures; wet; etching; substrate; cover; plate; joined; direct; bonding; capillary; electrophoresis; electrochromatography; performed; channels; formed; analytes; loaded; four-way; intersection; electrokinetically; pumping; analyte; followed; switching; potentials; force; plug; separation; channel; chemical separations; separation channel; chemical wet; performing microfluidic; microfluidic manipulations; photolithographic procedures; plate joined; standard photolithographic; channels formed; chemical analysis; capillary electrophoresis; cover plate; sample injection; wet etching; microchip chemical; microchip laboratory; direct bonding; including sample; electrokinetically pumping; fluid manipulations; four-way intersection; analyte plug; chemical separation; fluidic manipulations; proved fluid; lithographic procedures; /204/

Citation Formats

Ramsey, J Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis. United States: N. p., 2000. Web.
Ramsey, J Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis. United States.
Ramsey, J Michael. Sat . "Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis". United States. https://www.osti.gov/servlets/purl/872793.
@article{osti_872793,
title = {Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis},
author = {Ramsey, J Michael},
abstractNote = {A microchip laboratory system and method proved fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

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Works referenced in this record:

Electroosmosis: A Reliable Fluid Propulsion System for Flow Injection Analysis
journal, June 1994


Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights
journal, October 1993


Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights
journal, October 1993


Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation, and separation efficiency
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Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices
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High-Speed Separations on a Microchip
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Electric sample splitter for capillary zone electrophoresis
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Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip
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Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip
journal, August 1993


Capillary electrophoresis and sample injection systems integrated on a planar glass chip
journal, September 1992


Capillary electrophoresis and sample injection systems integrated on a planar glass chip
journal, September 1992