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Title: Apparatus and method for performing microfluidic manipulations for chemical analysis

Abstract

A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.

Inventors:
 [1]
  1. (Knoxville, TN)
Issue Date:
Research Org.:
LOCKHEED MARTIN ENRGY SYST INC
OSTI Identifier:
872745
Patent Number(s):
6001229
Assignee:
Lockheed Martin Energy Systems, Inc. (Oak Ridge, TN) ORNL
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
apparatus; method; performing; microfluidic; manipulations; chemical; analysis; microchip; provide; fluidic; variety; applications; including; sample; injection; liquid; chromatography; fabricated; standard; photolithographic; procedures; wet; etching; substrate; cover; plate; joined; direct; bonding; capillary; electrophoresis; performed; channels; formed; injections; electro-osmotically; pumping; channel; crosses; separation; followed; switching; potentials; force; plug; separation channel; chemical wet; liquid chromatograph; performing microfluidic; microfluidic manipulations; photolithographic procedures; plate joined; standard photolithographic; channels formed; chemical analysis; capillary electrophoresis; liquid chromatography; cover plate; sample injection; method provide; wet etching; provide fluid; direct bonding; including sample; fluidic manipulations; lithographic procedures; /204/

Citation Formats

Ramsey, J. Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis. United States: N. p., 1999. Web.
Ramsey, J. Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis. United States.
Ramsey, J. Michael. Fri . "Apparatus and method for performing microfluidic manipulations for chemical analysis". United States. https://www.osti.gov/servlets/purl/872745.
@article{osti_872745,
title = {Apparatus and method for performing microfluidic manipulations for chemical analysis},
author = {Ramsey, J. Michael},
abstractNote = {A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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