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Title: Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

Abstract

A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.

Inventors:
 [1]
  1. Knoxville, TN
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
OSTI Identifier:
874857
Patent Number(s):
6475363
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
apparatus; method; performing; microfluidic; manipulations; chemical; analysis; synthesis; microchip; laboratory; provide; fluid; variety; applications; including; sample; injection; separations; fabricated; standard; photolithographic; procedures; wet; etching; substrate; cover; plate; joined; direct; bonding; capillary; electrophoresis; electrochromatography; performed; channels; formed; analytes; loaded; four-way; intersection; electrokinetically; pumping; analyte; followed; switching; potentials; force; plug; separation; channel; wet etching; microfluidic manipulations; performing microfluidic; including sample; microchip chemical; microchip laboratory; fluid manipulations; provide fluid; /204/

Citation Formats

Ramsey, J Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis. United States: N. p., 2002. Web.
Ramsey, J Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis. United States.
Ramsey, J Michael. Tue . "Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis". United States. https://www.osti.gov/servlets/purl/874857.
@article{osti_874857,
title = {Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis},
author = {Ramsey, J Michael},
abstractNote = {A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

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Works referenced in this record:

Integrated Electrophoresis Systems for Biochemical Analyss
conference, June 1994


High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device
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Open Channel Electrochromatography on a Microchip
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Open Channel Electrochromatography on a Microchip
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