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Title: Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions

Abstract

The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients.

Inventors:
 [1];  [2];  [3];  [1]
  1. Setauket, NY
  2. Middle Island, NY
  3. Stony Brook, NY
Issue Date:
Research Org.:
Associated Universities, Inc., Upton, NY (United States)
OSTI Identifier:
872063
Patent Number(s):
5853695
Application Number:
08/743,287
Assignee:
Brookhaven Science Associates LLC (Upton, NY)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; palliation; pain; human; bone; cancer; therapeutic; tin-117m; compositions; provides; due; administration; unique; dosage; sn-117m; stannic; chelate; complex; pharmaceutically; acceptable; composition; addition; simultaneous; radiotherapy; patients; containing; chelates; palliating; sn-117m-containing; monitoring; patient; status; imaging; distribution; provided; complexes; bone pain; compositions containing; pharmaceutically acceptable; cancer patient; sn-117m chelate; compositions contain; bone cancer; /424/999/600/

Citation Formats

Srivastava, Suresh C, Meinken, George E, Mausner, Leonard F, and Atkins, Harold L. Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions. United States: N. p., 1998. Web.
Srivastava, Suresh C, Meinken, George E, Mausner, Leonard F, & Atkins, Harold L. Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions. United States.
Srivastava, Suresh C, Meinken, George E, Mausner, Leonard F, and Atkins, Harold L. Tue . "Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions". United States. https://www.osti.gov/servlets/purl/872063.
@article{osti_872063,
title = {Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions},
author = {Srivastava, Suresh C and Meinken, George E and Mausner, Leonard F and Atkins, Harold L},
abstractNote = {The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {12}
}

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Works referenced in this record:

Biodistribution of Sn-117m(4+)DTPA for palliative therapy of painful osseous metastases.
journal, January 1993