Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions

Srivastava, Suresh C; Meinken, George E; Mausner, Leonard F; Atkins, Harold L

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Title: Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions

Abstract

The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients.

Inventors:

Srivastava, Suresh C ^[1]; Meinken, George E ^[2]; Mausner, Leonard F ^[3]; Atkins, Harold L ^[1]

Setauket, NY
Middle Island, NY
Stony Brook, NY

Issue Date:: 1998-12-29

Research Org.:: Associated Universities, Inc., Upton, NY (United States)

OSTI Identifier:: 872063

Patent Number(s):: 5853695

Application Number:: 08/743,287

Assignee:: Brookhaven Science Associates LLC (Upton, NY)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2121/00 - Preparations for use in therapy
A61K2123/00 - Preparations for testing in vivo
A61K51/0478 - {complexes from non-cyclic ligands, e.g. EDTA, MAG3}
A61K51/0489 - {Phosphates or phosphonates, e.g. bone-seeking phosphonates

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P19/00 - Drugs for skeletal disorders
A61P19/08 - for bone diseases, e.g. rachitism, Paget's disease
A61P25/04 - Centrally acting analgesics, e.g. opioids
A61P35/00 - Antineoplastic agents

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DOE Contract Number:: AC02-76CH00016

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: method; palliation; pain; human; bone; cancer; therapeutic; tin-117m; compositions; provides; due; administration; unique; dosage; sn-117m; stannic; chelate; complex; pharmaceutically; acceptable; composition; addition; simultaneous; radiotherapy; patients; containing; chelates; palliating; sn-117m-containing; monitoring; patient; status; imaging; distribution; provided; complexes; bone pain; compositions containing; pharmaceutically acceptable; cancer patient; sn-117m chelate; compositions contain; bone cancer; /424/999/600/

Citation Formats


                    Srivastava, Suresh C, Meinken, George E, Mausner, Leonard F, and Atkins, Harold L. Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions.  United States: N. p., 1998. 
        Web.

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                    Srivastava, Suresh C, Meinken, George E, Mausner, Leonard F, & Atkins, Harold L. Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions.  United States.

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                    Srivastava, Suresh C, Meinken, George E, Mausner, Leonard F, and Atkins, Harold L. Tue .  
        "Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions".  United States.  https://www.osti.gov/servlets/purl/872063.

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@article{osti_872063,

  title        = {Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions},

  author       = {Srivastava, Suresh C and Meinken, George E and Mausner, Leonard F and Atkins, Harold L},

  abstractNote = {The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1998},

  month        = {12}

}

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Works referenced in this record:

Biodistribution of Sn-117m(4+)DTPA for palliative therapy of painful osseous metastases.
journal, January 1993

Atkins, H. L.; Mausner, L. F.; Srivastava, S. C.
Radiology, Vol. 186, Issue 1
https://doi.org/10.1148/radiology.186.1.7677974

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Similar Records

Title: Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions

Abstract

Citation Formats

Biodistribution of Sn-117m(4+)DTPA for palliative therapy of painful osseous metastases. journal, January 1993

Biodistribution of Sn-117m(4+)DTPA for palliative therapy of painful osseous metastases.
journal, January 1993