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Title: Formulation for Tin-.sup.117m /diethylenetriaminepentaacetic acids

Patent ·
OSTI ID:872770
 [1];  [2]
  1. Setauket, NY
  2. Middle Island, NY
+ Show Author Affiliations

The invention provides improved formulations of .sup.117m Sn (Sn.sup.4+) DTPA which allow higher doses of .sup.117m Sn (Sn.sup.4+) to be administered than were previously possible. Methods for making pharmaceutical compositions comprising .sup.117m Sn (Sn.sup.4+) DTPA in which the amount of unchelated DTPA is minimized are disclosed along with methods of using the improved formlulations, both for palliation of bone pain associated with cancer and for treatment of osseous tumors.

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
DOE Contract Number:
AC02-98CH10886
Assignee:
Brookhaven Science Associates (Upton, NY)
Patent Number(s):
US 6004532
OSTI ID:
872770
Country of Publication:
United States
Language:
English

References (4)

Improved specific activity of reactor produced 117mSn with the Szilard-Chalmers process
  • Mausner, L. F.; Mirzadeh, S.; Srivastava, S. C.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 43, Issue 9, p. 1117-1122 https://doi.org/10.1016/0883-2889(92)90053-H
journal September 1992
Cancer therapy using bone-seeking isotopes journal October 1996
Biodistribution of Sn-117m(4+)DTPA for palliative therapy of painful osseous metastases. journal January 1993
Tin-117m: Production, chemistry and evaluation as a bone-scanning agent journal June 1973

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Related Subjects

formulation
tin-
117m
diethylenetriaminepentaacetic
acids
provides
improved
formulations
dtpa
allow
doses
administered
previously
methods
pharmaceutical
compositions
comprising
amount
unchelated
minimized
disclosed
formlulations
palliation
bone
pain
associated
cancer
treatment
osseous
tumors
pharmaceutical compositions
bone pain
acetic acid
provides improved
compositions comprising
pharmaceutical composition
/424/999/600/